UJI EFEKANTIINFLAMASI EKSTRAKETANOL BUNGA ROSELA(HIBISCUS sabdariffa Linn.)PADA TIKUS PUTIH JANTAN (Rattus norvegicus)

Abstract

An antiinflamatory effect test ofroselaflowers (hibiscus sabdwiffa Linn.) on male rats (Rattus norvegicus)had been carried out. The aim ofthis research is to assay anti-inflamatory effect of rosela extract flowers based on the reduction volume of legs edema inmale rats which induced with albumin 15 male rats divided into 5 groups and each group consisted of 3 rats. control group was given Na-CMC 1% w/v, 2nd ,3\'d and 4 groups were given rosela extract. flowers each 2,5% w/v, 5% w/v and 7,5% respsctively and 5th group was given natrium diclofenac suspension as psitive control. All treatment were given orally with dosage 5 mL/400g body weight. Legs of male rats was signed and measured as first volume using platysmometer, one hour later 0,2 mL albumin sohrtion 1% v/v wasinjected by intraplantary into legs of male rats to induce inflammation and measured as edema volume.Measurement of legs volume was conduct 3 hours with interval 30 minutes. The resrlts showed that all the concentration ofrosella extract flowers were reduced the edema volum, the effect ofreduction edema volume rosela extract flowers 7,5% w/v better than the effect of diclofenac suspension statifically.