Viqa Faiqah, Nadirah Rasyid Ridha


Non-Hodgkin’s Lymphoma (NHL) is a large group of malignant neoplasms originating in the lymph nodes and extra nodes of lymphoid tissues. This kind of malignancy is quite common in the world with 3% of all cancer cases. In Indonesia, NHL is the 6th most common cancer and is the third most rapidly progressive cancer after melanoma and lung cancer. The novelty in this study is diffuse large cell non hodgkin lymphoma at retrobular occulus sinistra mass. A 15-years-old boy came with complaints of a protruding left eye since 2 months ago, begin with reddish eyes which gradually enlarged and decrease of visual function. Biopsy confirmed the diagnose as a stage 2 non-Hodgkin's lymphoma with Diffuse large cells. This patient underwent a chemotherapy procedure according to the non-Hodgkin's lymphoma’s protocol for 1 year that turn out in decrease of tumor progression and good result of the chemotherapy. A case of retrobulbar mass occulus sinistra et causa non-Hodgkin's lymphoma in a 15 year old boy. Diagnose is based on history, physical examination, laboratory tests and biopsy. Treatment of this patient using chemotherapy regimens according to the non-Hodgkin's lymphoma protocol.


15 years old boy; Case report; Chemotherapy; Non-Hodgkin Lymphoma; Retrobulbar occulus left

Full Text:



Winkfield KM, Tsang RW, Gospodarowicz MK. Non-Hodgkin’s Lymphoma. In: Clinical Radiation Oncology. 7th ed. Elsevier; 2016. p. 1524–46.

Windiastuti E, Movieta Y, Mulatsih S. Buku Ajar Hematologi Anak. Jakarta: Badan Penerbit Ikatan Dokter Anak Indonesia; 2018.

Nogai H, Dörken B, Lenz G. Pathogenesis of Non-Hodgkin’s Lymphoma. Journal of Clinical Oncology. 2011 May 10;29(14):1803–11.

American Cancer Society. What Is Non-Hodgkin Lymphoma? 2018.

Jiang L, Li N. B-cell non-Hodgkin lymphoma: importance of angiogenesis and antiangiogenic therapy. Angiogenesis. 2020 Nov 25;23(4):515–29.

The Leukemia & Lymphoma Society. Non-Hodgkin Lymphoma. 2013.

Soebagjo H, Nurwasis, Supartoto A, Fatmariyanti S. Onkologi Mata. Surabaya: Airlangga University Press; 2019. 51–52 p.

Foster JA, Carter K, Durairaj V, Kavanagh MC, Korn BS, Nelson CC, et al. Orbit, Eyelids, and Lacrimal System. In: Basic and Clinical Science Course. San Francisco: American Academy of Ophthalmology; 2019. p. 51–2.

Moustafa GA, Topham AK, Aronow ME, Vavvas DG. Paediatric ocular adnexal lymphoma: a population-based analysis. BMJ Open Ophthalmol. 2020 Jun 21;5(1):e000483.

Lucas JT, Greven CM, Greven KM. Orbital, Ocular, and Optic Nerve Tumors. In: Clinical Radiation Oncology. 6th ed. Elsevier; 2016. p. 541–60.

Chaurasiya BD, Agrawal G, Chaudhary S, Shah S, Pradhan A, Lavaju P. Orbital Lymphoma Masquerading as Orbital Cellulitis. Case Rep Ophthalmol Med. 2021 Sep 9;2021:1–5.

Payandeh M, Sadeghi M, Sadeghi E. The Ki-67 index in non-Hodgkin’s Lymphoma: Role and Prognostic Significance. Am J Cancer Prev . 2015;3(5):100–2.

Priego G, Majos C, Climent F, Muntane A. Orbital lymphoma: imaging features and differential diagnosis. Insights Imaging. 2012 Aug 18;3(4):337–44.

Graue GF, Finger PT, Maher E, Rocca D Della, Rocca R Della, Lelli GJ, et al. Ocular Adnexal Lymphoma Staging and Treatment: American Joint Committee on Cancer versus Ann Arbor. Eur J Ophthalmol. 2013 May 25;23(3):344–55.

Sharma T, Kamath MM. Diagnosis and Management of Orbital Lymphoma. India; 2015.

Rahmi MR, Rahman A. Orbital Lymphoma: Clinical Features and Management at Dr. M. Djamil General Hospital in 2018. Bioscientia Medicina : Journal of Biomedicine and Translational Research. 2022 Jun 27;6(9):2144–8.

Eckardt AM, Lemound J, Rana M, Gellrich NC. Orbital lymphoma: diagnostic approach and treatment outcome. World J Surg Oncol. 2013 Dec 18;11(1):73.

Amit S, Purwar N, Agarwal A, Kanchan S. Primary orbital non-Hodgkin’s lymphoma. Case Reports. 2012 Oct 19;2012(oct19 1):bcr2012006847–bcr2012006847.

Olsen TG, Heegaard S. Orbital lymphoma. Surv Ophthalmol. 2019 Jan;64(1):45–66.

DOI: https://doi.org/10.35971/gojhes.v7i4.20751


  • There are currently no refbacks.