COMPARISON OF TRANSFERRIN SATURATION LEVELS IN ANEMIA OF CHRONIC DISEASE AND IRON DEFICIENCY ANEMIA: A CROSS-SECTIONAL STUDY
Abstract
About 33 percent of the global population is anemic. Anemia of chronic disease (ACD) is caused by chronic inflammation. Iron deficiency anemia (IDA) is caused by a decrease in the body's iron reserves to form red blood cells. There are many clinical and laboratory similarities between ACD and IDA, but the treatment is very different. Transferrin saturation level can be used to differentiate between the two. This research is novel because it compares transferrin saturation levels in chronic and iron deficiency anemia. This study aims to determine the transferrin saturation level in patients with ACD and IDA. This research method uses a cross-sectional study. Data taken from medical records. The sample for this study were children with ACD and IDA aged 1 month to 18 years at Wahidin Sudirohusodo Hospital, Makassar. The results showed that the mean transferrin saturation value in DKA children (19.40%) was higher than that in ADB children (5.66%). The Mann-Whitney test showed that there was a significant difference between the two groups (p=0.001) with a transferrin saturation cut-off point between the DKA and IDA groups of 6.5% with a sensitivity of 73.6%, a specificity of 72.5%, positive predictive value (PPV) of 78%, negative predictive value (NPV) of 67%, and odds ratio (OR) of 19,476 (95% CI). In conclusion, transferrin saturation levels can differentiate IDA and ACD using a cut-off point of 6.5%.
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Madu AJ, Ughasoro MD. Anaemia of Chronic Disease: An In-Depth Review. Med Princ Pract [Internet]. 2017;26(1):1–9. Tersedia pada: https://www.karger.com/Article/FullText/452104
Mahajan G, Sharma S, Chandra J, Nangia A. Hepcidin and iron parameters in children with anemia of chronic disease and iron deficiency anemia. Blood Res [Internet]. 2017;52(3):212. Tersedia pada: https://synapse.koreamed.org/DOIx.php?id=10.5045/br.2017.52.3.212
Cacoub P, Vandewalle C, Peoc’h K. Using transferrin saturation as a diagnostic criterion for iron deficiency: A systematic review. Crit Rev Clin Lab Sci [Internet]. 17 November 2019;56(8):526–32. Tersedia pada: https://www.tandfonline.com/doi/full/10.1080/10408363.2019.1653820
Purnamasari R. Anemia Defisiensi Besi. Buku Ajar Hematologi Onkologi Anak. Edisi Revisi. Jakarta; 2018. 27–39 hal.
World Health Organization. Child growth standards [Internet]. Tersedia pada: https://www.who.int/tools/child-growth-standards/standards/weight-for-age
CDC. Kurva Pertumbuhan [Internet]. 2000. Tersedia pada: https://www.idai.or.id/downloads/CDC/Kurva-pertumbuhan-CDC-2000-lengkap.pdf
World Health Organization (WHO). Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. 2020.
Ben-David Y, Koren A, Colodner R, Levin C. Characterization of acquired anemia in children by iron metabolism parameters. Sci Rep [Internet]. 17 Februari 2022;12(1):2721. Tersedia pada: https://www.nature.com/articles/s41598-022-06574-0
Jain S, Narayan S, Chandra J, Sharma S, Jain S, Malhan P. Evaluation of serum transferrin receptor and sTfR ferritin indices in diagnosing and differentiating iron deficiency anemia from anemia of chronic disease. Indian J Pediatr [Internet]. 20 Februari 2010;77(2):179–83. Tersedia pada: http://link.springer.com/10.1007/s12098-009-0302-z
Windiastuti E, dkk. Anemia Penyakit Kronis. Buku Ajar Hematologi Onkologi Anak.Edisi Revisi. Jakarta: Badan Penerbit FK UI; 2018. 53–59 hal.
Higgins V, Chan MK, Adeli K. Pediatric Reference Intervals for Transferrin Saturation in the CALIPER Cohort of Healthy Children and Adolescents. EJIFCC [Internet]. 17 Maret 2017;28(1):77–84. Tersedia pada: https://www.tandfonline.com/doi/full/10.1080/10408363.2019.1653820
Teke HU, Cansu DU, Yildiz P, Temiz G, Bal C. Clinical significance of serum IL-6, TNF-α, hepcidin, and EPO levels in anaemia of chronic disease and iron deficiency anaemia: The laboratory indicators for anaemia. Biomed Res. 2017;28(6):2704–10.
Peng YY, Uprichard J. Ferritin and iron studies in anaemia and chronic disease. Ann Clin Biochem Int J Lab Med [Internet]. 7 Januari 2017;54(1):43–8. Tersedia pada: http://journals.sagepub.com/doi/10.1177/0004563216675185
Sianipar SS, Suryagustina S, Paska M. Effect Of Health Education Using Media Audio Visual On Knowledge About Anemia In Adolescent Women In High School. Jambura J Heal Sci Res [Internet]. 23 Desember 2022;5(1):119–31. Tersedia pada: https://ejurnal.ung.ac.id/index.php/jjhsr/article/view/17029
Yuniarti W. Anemia In Chronic Kidney Disease Patients. J Heal Sci Gorontalo J Heal Sci Community [Internet]. 31 Oktober 2021;5(2):341–7. Tersedia pada: https://ejurnal.ung.ac.id/index.php/gojhes/article/view/11632
DOI: https://doi.org/10.37905/ijhsmr.v2i2.18769
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