Characterization of the manufacturing process simplicia Syzygium aromaticum as raw material for wound healing drug preparations

Naziella Naziella, Wintari Taurina, Mohamad Andrie

Abstract


Characterization is the first step before standardization. Standardization of a drug substance is a requirement to achieve parameters that will ensure constant quality in a preparation. The main compounds contained in clove leaves have analgesic and antibacterial properties to accelerate wound healing. This study aims to characterize the process of making clove leaf simplicia and Simplicia (Syzygium aromaticum) originating from Lemukutan Island, Bengkayang Regency, West Kalimantan as raw material for wound healing drug preparations. Clove leaf Simplicia was characterized biologically including habitat and morphology, physically including organoleptic, microscopic, moisture content, ash content, and acid insoluble ash content, and chemically, namely phytochemical screening. Making clove leaf Simplicia consists of harvesting, wet sorting, washing, drying, dry sorting, packaging, and storage. The yield of clove leaf Simplicia was obtained as much as 70.90%. The results of the characterization of clove leaves showed that the clove tree grows in the highlands, with a tropical climate, with a temperature range of 25 C-32 C. Clove leaves are oval in shape, tapered tip, pinnate leaf bone, leaf length is approximately 9-12 cm and width 4 cm-4.5 cm. The moisture content, ash content, and insoluble ash content of the clove leaf Simplicia powder were 9.21%, 3.05%, and 0.69%, respectively. The outcomes of the phytochemical screening of clove leaf Simplicia powder have beensuperbfor holding flavonoids, saponins, triterpenoids, and tannins.

Keywords


Characterization, Simplicia Clove leaf (Syzygium aromaticum), Phytochemical screening, Medicinal raw materials

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References


A. Najib, A. Malik, A. R. Ahmad, V. Handayani, R. A. Syarif, and R. Waris, “standardisasi ekstrak air daun jati belanda dan daun jati hijau,” J. Fitofarmaka Indones., vol. 4, no. 2, pp. 241–245, 2018.

D. K. Chanchal, P. Niranjan, S. Alok, and S. Kulshreshta, “A Brief Review on Medicinal Plant and Screening Method of Antilithiatic Activity,” Int. J. Pharmacogn., vol. 3, no. 1, pp. 1–9, 2016, doi: 10.13040/IJPSR.0975-8232.IJP.3(1).1-09.

M. Salim, N. Sulistyaningrum, I. Ani, H. Sitoris, Yahya, and T. Ni’mah, “Karakterisasi Simplisia dan Ekstrak Kulit Buah Duku ( Lansium domesticum Corr ) dari Provinsi Sumatera Selatan dan Jambi,” J. Kefarmasian Indones., vol. 6, no. 2, pp. 117–128, 2016.

R. Supriningrum, N. Fatimah, and E. Purwanti, “karakterisasi spesifik dan non spesifik ekstrak etanol daun putat,” Al Ulum Sains Dan Teknol., vol. 5, no. 1, pp. 6–12, 2019.

D. M. Taher, D. D. Solihin, U. Cahyaningsih, and P. Sugita, “Ekstrak Metanol Cengkeh (Syzygium aromaticum (L.) Merry & Perry) Varietas Tuni Buru Selatan sebagai Antimalaria,” Acta Vet. Indones., vol. 6, no. 2, pp. 38–47, 2018, doi: 10.29244/avi.6.2.38-47.

M. Fauziah and F. Soniya, “Potensi Tanaman Zigzag sebagai Penyembuh Luka,” J. Penelit. Perawat Prof., vol. 2, no. 1, pp. 39–44, 2020, doi: 10.37287/jppp.v2i1.41.

F. R. Tulungen, “Cengkeh Dan Manfaatnya Bagi Kesehatan Manusia Melalui Pendekatan Competitive Intelligence,” J. Biofarmasetikal Trop., vol. 2, no. 2, pp. 158–169, 2019.

M. Andrie and W. Taurina, “In Vitro Antibacterial Effectiveness Test of Several Herbal Plant Extract in an Attempt to Discover the Strongest Antibacterial Herbal Topical Againt Staphylococus Aureus and Pseudomonas Aeruginosae,” Eur. J. Biomed. Pharm. Sci., vol. 6, no. 12, pp. 375–379, 2019.

F. Daisa, M. Andrie, and W. Taurina, “The Effectiveness Test of Oil Phase Ointment Containing Snakehead Fish ( Channa striata ) Extract on Open Stage II Acute Wounded Wistar Strain Male Rats,” Tradit. Med. J., vol. 22, no. August, pp. 10–11, 2017.

M. Andrie and W. Taurina, “Penetapan waktu kadarluarsa salep ekstrak ikan gabus (Channa striata) melalui uji stabilitas jangk panjang (real time) menggunalan variasi gelling agent dengan parameter fisik, kimia dan mikrobiologi.” PTUPT, 2021.

W. N A and C. N, “Pengaruh Olesan Minyak Cengkeh (Syzygium aromaticum L) Terhadap Proses Penyembuhan Luka Insisi Pada Hewan Coba Mencit(Mus musculus) Strain Balb/ C,” J. Keperawatan Muhammadiyah, vol. 2, no. 1, 2017.

S. Wael, F. Mahulette, T. Wilhelmus Watuguly, and D. Wahyudi, “Pengaruh Ekstrak Daun Cengkeh (Syzygium aromaticum) terhadap Limfosit dan Makrofag Mencit Balb/c,” Jalan Yos Sudarso No 338 Serengan, vol. 23, no. 2, pp. 79–83, 2018.

K. Kaur and S. Kaushal, “Phytochemistry and pharmacological aspects of Syzygium aromaticum : A Phytochemistry and pharmacological aspects of Syzygium aromaticum : A review,” no. January, 2019.

S. L. Merr, “Morphological Traits of Maluku Native Forest Clove,” vol. 6, no. 2, pp. 105–111, 2019.

A. Isnaeni and Y. Sugiarto, “Kajian Kesesuaian Lahan Tanaman Cengkeh Berdasarkan Aspek Agroklimat dan Kelayakan Ekonomi (Studi Kasus Provinsi Sulawesi Selatan),” vol. 24, no. 2, pp. 39–47, 2010.

Suwarto and Dkk, tanaman perkebunan, vol. 8, no. 2. 2014.

U. Mayasari and M. T. Laoli, “Karakterisasi Simplisia Dan Skrining Fitokimia Daun Jeruk Lemon ( Citrus Limon ( L .) Burm . F .),” Klorofil, vol. 2, no. 1, pp. 7–13, 2018.

F. Handayani, A. Apriliana, and I. Novianti, “Karakterisasi Dan Skrining Fitokimia Simplisia Buah Selutui Puka (Tabernaemontana macracarpa Jack),” J. Ilm. -Syifaa, vol. 12, no. 1, pp. 9–15, 2020, doi: 10.33096/jifa.v12i1.577.

Y. P. Utami, A. H. Umar, R. Syahruni, and I. Kadullah, “Standardisasi Simplisia dan Ekstrak Etanol Daun Leilem ( Clerodendrum,” J. Pharm. Med. Sci., vol. 2, no. 1, pp. 32–39, 2017.

Departemen Kesehatan Republik Indonesia, Farmakope Herbal Indonesia, II. Jakarta: Departemen Kesehatan Republik Indonesia, 2017. doi: 10.1201/b12934-13.




DOI: https://doi.org/10.37311/jsscr.v4i2.14184

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