Uji Aktivitas Antioksidan Sediaan Salep Ikan Gabus (Channa Striata) Kombinasi Vitamin C dan Madu Kelulut (Heterotrigona Itama)

Risma Dwi Anugerah, Wintari Taurina, Mohamad Andrie

Abstract


Based on the results of research, snakehead fish extract and kelulut honey have properties to make wounds heal faster. Ointment with an active formulation of snakehead fish extract and extract of kelulut honey showed an oxidation process that could make the preparation rancid. The addition of BHA and Vitamin C is expected to prevent the oxidation process so that the preparation does not become rancid. This study aims to determine the effect of adding Antioxidant BHA and Vitamin C in preventing the oxidation process of the ointment in the aqueous phase of extracts of snakehead fish (Channa Striata)and of kelulut honey (Heterotrigona Itama) at 28 days storage. Stability was accelerated at a temperature of 40 ± 20ºC and a RH of 75 ± 5%. Variations in the concentration ofiBHA and Vitamin C used were BHA.0.02. : Vitamin C 0.1, BHA 0.02 : Vitamin C 0.01, BHA 0.005 : Vitamin C 0.01, and BHA 0.005 : Vitamin C 0.1 then tested the physical properties of the ointment, namely through organoleptic test, homogeneity test, spreadability test, adhesion test, protection test and acid number test which were then analyzed by SPSS. Based on the analysis of the scattering power showed a significant difference between F0, F1, and F3. The results of the adhesion analysis showed that there were significant differences in each formula. Furthermore, the results of the stability test showed that all formulas had good physical stability. Conclusion: F1 is a very good formula to prevent oxidation in the preparation as evidenced by a decreased acid number, which is 9.62 mg KOH/g.

Keywords


Snakehead Fish, Kelulut Honey, BHA, Vitamin C, Accelerated Stability

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References


Departemen Kesehatan Republik Indonesia. FarmakopeiiIndonesia 4. Edisi Keem. Jakarta; 1995.

Elmitra. Dasar-Dasar Farmasetika dan Sediaan Semi Solid. Yogyakarta; 2017.

Andrie M, Sihombing D. Efektivitas Sediaan Salep yang Mengandung Ekstrak Ikan Gabus (Channa Striata)pada Proses Penyembuhan Luka Akut Stadium II Terbuka pada Tikus Jantan Galur Wistar The Effectiveness of Snakehead (Channa Striata)Extract- Containing Ointment on Healing Proce. Pharm Sci Res ISSN Pharm Sci Res [Internet]. 2017;4 (2): 88–101. Available from:psr.ui.ac.id/index.php/journal/article/download/3602/644.

Fitriyani E, Deviarni IM. Pemanfaatan Ekstak Albumin Ikan Gabus ( hanna Striata) Sebagai Bahan Dasar Cream Penyembuhan Luka. Vokasi. 2013;9(3):166–74.

Gorada, Wintari Taurina MA. Formulasi Sediaan Salep Madu Kelulut ( Heterotrigona Itama ) Dan Fase Air Ekstrak Ikan Gabus ( Channa Striata ). J Mhs Farm Fak Kedokt UNTAN [Internet]. 2019;(Vol 4, No 1 (2019): Jurnal Farmasi Kalbar). Available from: http://jurnal.untan.ac.id/index.php/jmfarmasi/arti cle/ view/33514

Hasrawati A, Famir Y, Mursyid AM. Formulasi Dan Evaluasi Salep Ekstrak Daun Gulma Siam ( Chromollaena Odorata L) Dengan Variasi Basis Salep. 2019;11(01):55–60.

Phatangare Jyoti Kundan, Deore Sharada Laxman PKE. Research Article Stability Evaluation Of Topical Ointment Comprising Calcipotriol And. Phatangare Jyoti Kundan al Int Res J Pharm. 2015;6(1):43–7.

Sehro, Sri Luliana RD. Pengaruh Penambahan Tea (Trietanolamine) Terhadap Ph Basis Lanolin Sediaan Losio Sehro,. 2015;4–9.

Husain R, Suparmo, Harmayani E, Hidayat C. Komposisi Asam Lemak, Angka Peroksida, dan Angka TBA Fillet Ikan Kakap (Lutjanus sp) pada Suhu dan Lama Penyimpanan Berbeda. 2017;37(3):319–26.

Fitri N. Butylated hydroxyanisole sebagai Bahan Aditif1Antioksidan pada Makanan dilihat dari Perspektif Kesehatan. J Kefarmasian Indonesia. 2014; 4(1): 41–50.

Almatsier S. Prinsip Dasar Ilmu Gizi. Jakarta: Gramedia Pustaka Utama; 2004.

Sun N, Factor P, Dari SPF, Metoksisinamat O. Pengaruh Penambahan Vitamin C Sebagai Antioksidan Terhadap Nilai Sun Proctective Factor ( Spf ) Dari Pros Snija. 2015;(January):114–7.

Wibawa JC, Wati LH, Arifin MZ. Mekanisme Vitamin C Menurunkan Stres Oksidatif Setelah Aktivitas Fisik. JOSSAE J Sport Sci Educ. 2020;5(1):57.

Schanno R, Westlund J, Foelsch D. Evaluation of1,3-dimethylol-5,5-dimethyl hydantoin as a Cosmetic Preservative. J Soc Cosmet Chem. 1980;31(2):85–96.

Nugroho M. Pengaruh Suhu dan Lama Ekstraksi secara Pengukusan terhadap Rendemen dan Kadar Albumin Ikan Gabus (Ophiocephalus striatus). J Saintek Perikan. 2013;8(2):38–9.

L A, L. W. Uji Aktivitas Antinyamuk Lotion Minyak Kunyit Sebagai AlternatifiiPencegah Penyebaran Demam Berdarah Dengue. J Trop Pharm Chem. 2011;1(2).

Andarina R, Djauhari T. Antioksidan dalam dermatologi. JKK. 2017;4(1):45–6.

Gandjar I. Kimia Farmasi Analisis. Yogyakarta: Pustaka Pelajar; 2007.




DOI: https://doi.org/10.37311/jsscr.v4i3.15271

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