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Identification of Paracetamol in Jamu Using Thin Layer Chromatography Analysis Method
Abstract
Jamu is one of the Indonesian traditional medicine. Jamu is efficacious for health so it is widely consumed by the society. The high level of consumption causes trade competition from jamu industry in various regions, including in Pontianak City, West Kalimantan. However, several jamu industries in Pontianak have violated the law by adding medicinal chemicals to jamu. The most widely added medicinal chemical in jamu is paracetamol. Paracetamol which indicates as an analgesic-antipyretic can be harmful for health because it increases liver hepatotoxicity if consumed continuously.This study aims to identify paracetamol in herbal medicine. A total of 10 samples were obtained in Pontianak City, West Kalimantan by purchasing directly or from an online shop. This study used thin layer chromatography as an instrument of qualitative analysis. The results of the analysis using thin layer chromatography were Rf samples A, B, and G were 0.675, respectively; 0.6625; 0.6625 which is close to the standard Rf value for comparison of paracetamol, which is 0.675. Those three samples contained paracetamol because they had a different Rf value <0.05 from the standard Rf value.
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World Health Organization, WHO Global Report On Traditional and Complementary Medicine 2019. Geneva: World Health Organization, 2019.
Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan RI, “Riset Kesehatan Dasar,” 2010.
Z. Salim and E. Munadi, Info Komoditi Tanaman Obat, 1st ed. Jakarta: Badan Pengkajian dan Pengembangan Perdagangan Kementerian Perdagangan Republik Indonesia, 2017.
Badan Pengawas Obat dan Makanan Republik Indonesia, “Bahaya Bahan Kimia Obat (BKO) yang Dibubuhkan ke Dalam Obat Tradisional (Jamu),” 2006. https://www.pom.go.id/new/view/more/berita/144/BAHAYA-BAHAN-KIMIA-OBAT BKO YANG-DIBUBUHKAN-KEDALAM-OBAT-TRADISIONAL JAMU-.html.
Menteri Kesehatan Republik Indonesia, Peraturan Menteri Kesehatan Republik Indonesia Nomor 007 Tahun 2012 Tentang Registrasi Obat Tradisional. 2012.
Badan Pengawas Obat dan Makanan Republik Indonesia, “Public Warning No. HM.01.1.2.07.20.18 Tentang Obat Tradisional dan Suplemen Kesehatan Mengandung Bahan Kimia Obat.” Jakarta, 2020.
Badan Pengawas Obat dan Makanan Republik Indonesia, “Public Warning No. HM.01.1.2.10.21.45 Tentang Obat Tradisional Mengandung Bahan Kimia Obat.” Jakarta, 2021.
Badan Pengawas Obat dan Makanan Republik Indonesia, “BBPOM Pontianak Sita Kosmetik dan Obat Tradisional Illegal,” 2016. https://www.pom.go.id/new/view/more/berita/11923/BBPOM-Pontianak-Sita-Kosmetik-dan-Obat-Tradisional-Illegal.html.
S. M. Britza, I. F. Musgrave, and R. W. Byard, “Paracetamol (acetaminophen) hepatotoxicity increases in the presence of an added herbal compound,” Leg. Med., vol. 47, no. June, p. 101740, 2020, doi: 10.1016/j.legalmed.2020.101740.
S. S. Fauziah, F. Lestari, Y. Lukmayani, and H. A. W, “Pengaruh Pemberian Jamu Pegal Linu Mengandung Bahan Kimia Obat (Bko) terhadap Fungsi Hati Tikus Wistar Jantan,” Pros. Penelit. Sivitas Akad. Unisba, 2015.
L. Wulandari, Kromatografi Lapis Tipis, 1st ed. Jember: PT. Taman Kampus Presindo, 2011.
D. D. Indriatmoko, T. Rudiana, and A. Saefullah, “Analisis Kandungan Parasetamol Pada Jamu Pegal Linu yang Diperoleh dari Kawasan Industri Kecamatan Kibin Kabupaten Serang,” J. Itekimia, vol. 5, no. 1, 2019.
B. Wijianto and Yumanda, “Analisis Kandungan Parasetamol Pada Jamu Pegal Linu Di Pontianak Dengan Menggunakan Metode Kromatografi Lapis Tipis (KLT) Dan Spektrofotometri UV-Vis,” J. Penelit. Univ. Tanjungpura, vol. XXVI, pp. 1–13, 2012.
Kementerian Kesehatan Republik Indonesia, Farmakope Indonesia edisi VI. Jakarta, 2020.
A. Rohman, Analisis Farmasi dengan Kromatografi Cair. Yogyakarta: Gadjah Mada University Press, 2020.
S. Kumar, K. Jyotirmayee, and M. Sarangi, “Thin Layer Chromatography: A Tool of Biotechnology for Isolation of Bioactive Compounds from Medicinal Plants,” Int. J. Pharm. Sci. Rev. Res., vol. 18, no. 1, pp. 126–132, 2013.
E. Rosamah, Kromatografi Lapis Tipis Metode Sederhana Dalam Analisis Kimia Tumbuhan Berkayu. Samarinda: Mulawarman University Press, 2019.
F. F. Mosy and Kuswandani, “Identifikasi Senyawa Jamu Pegal Linu yang Beredar di Kabupaten Bantul dengan Metode Kromatografi Lapis Tipis,” Surya Med. J. Ilm. Ilmu Keperawatan dan Ilmu Kesehat. Masy., vol. 14, no. 2, pp. 80–85, 2019.
M. A. U. Leba, Ekstraksi dan Real Kromatografi, 1st ed. Yogyakarta: Deepublish, 2017.
F. Husna and S. R. Mita, “Identifikasi Bahan Kimia Obat dalam Obat Tradisional Stamina Pria dengan Metode Kromatografi Lapis Tipis,” Farmaka, vol. 18, no. 2, pp. 16–25, 2020.
D. E. Oktaviantari, N. Feladita, and R. Agustin, “Identifikasi Hidrokuinon dalam Sabun Pemutih Pembersih Wajah Pada Tiga Klinik Kecantikan di Bandar Lampung dengan Metode Kromatografi Lapis Tipis dan Spektrofotometri UV-Vis,” J. Anal. Farm., vol. 4, no. 2, pp. 91–97, 2019.
DOI: https://doi.org/10.37311/jsscr.v4i3.15284
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