Potensi Interaksi Obat Antidiabetes Melitus Tipe-2 dengan Obat Antihipertensi

Widy Susanti Abdulkadir, Endah Nurrohwinta Djuwarno, Nur Rasdianah, Juliyanty Akuba, Mimi Fauziah Tahir

Abstract


The effect caused by the use of antidiabetic and antihypertensive drugs combination needs to be considered. The treatment therapy of the patient has the potential risk of drug interactions that are beneficial or detrimental to the patient. This study aims to determine the potential drug interactions in combinations of antidiabetic and antihypertensive drugs. This research is a descriptive study with a cross-sectional design and retrospective data collection. The sample used is medical records of diabetes mellitus patients with comorbid hypertension from January to December 2021 at Batudaa Public Health Center, Gorontalo Regency. The results showed that there were more female patients than male patients. Based on this study. there were 49 female patients (70%), while the largest age group of 50-59 years included 29 patients (41,43%). Whereas, those with the highest potential for drug interactions were metformin and amlodipine, totaling 54 patients (77%). The mechanism of interaction in this study was the pharmacodynamic phase, and the potential to cause the effect was hypoglycemic through the severity of the interaction was moderate level.

 


Keywords


Diabetes melitus type II; Hypertension; Drugs Interactions

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References


. American Diabetes Association. (2016). Standart of Medical Care in Diabetes. American Diabetes Association

. Kementerian Kesehatan RI. (2018). Hasil Riset Kesehatan Dasar (Riskesdas). Jakarta: Badan Penelitian dan Pengembangan Kesehatan Kementerian RI

. Marice Sihombing. (2017). Faktor risiko pada penyakit diabetes di Indonesia. Buletin Penelitian Sistem Kesehatan

. Gunawan, Sulistia Gan. Setiabudy, Rianto. Nafrialdi. Elysabeth.(2007). Farmakologi dan Terapi Edisi 5. Jakarta: FKUI.

. Trisnawati, S. K., & Setyorogo, S. (2013). Faktor risiko Kejadian diabetes mellitus tipe II di puskesmas kecamatan cengkareng Jakarta Barat Tahun 2012. Jurnal Ilmiah Kesehatan

. Cheekurthy, A. J. P., Rambabu, C., & Kumar, A. (2016).Prevalence of type 2 diabetes mellitus among women and the associated risk factors. Journal of Nursing and Health Sciences.

. Aru W.S, (2009), Buku Ajar Ilmu Penyakit Dalam, jilid II, edisi V, Jakarta: InternaPublishing.

. PERKENI. (2019).Pedoman Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 Dewasa di Indonesia. Jakarta

. Siregar, C.J.P. (2005).Farmasi Klinik:Teoridan Penerapan.Jakarta:EGC

. Akash MS, Rehman K, Chen S. (2013).Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus. In: J Cell Biochem

. Departemen Kesehatan RI. (2001). Keputusan Menteri Kesehatan Republik Indonesia Nomor 1239/MENKES/SK/III/2001 tentang Registrasi dan Praktik Perawat. Jakarta: Depkes RI

. Lakshmi, K., & Lakshmi (2012). Simultaneous Analysis of Losartan Potassium, Amlodipine Besylate, and Hydrochlorothiazide in Tablets by High-Performance thin layer Chromatography with UV-absorption densitometry. Journal of Analytical Methods in Chemistry

. Bell, Kaycee, June T, Bernie R. (2015). Hypertension : The Silent Killer : Update JNC 8 Guideline Recommendation. Wangshinton, Alabama: Pharmacy Assosiation

. Medscape. (2018). Drug Interaction Checker, (online), (http://www. reference.medscape.com/drug-interactionchecker), diakses tanggal 1 Desember 2022

. Dipiro, J. T., Talbert, R. L., Yee, G. C., Matzke, G. R., Wells, B. G., & Posey, L. M. (2014) Pharmacoteraphy: A Pathophysiologic Approach, ed. McGraw-Hill Medical, New York

. Eric, B. L. (2013). Glucose Levels and Risk of Dementia. New England Journal Medical

. Tatro, D.S., Hartshorn, E.A., (2009). Drug Interaction Facts, The Authority on Drug Interactions

. Nurul Annisa &Rizky Abdulah., (2012). Potensi Interaksi Obat Resep Pasien Geriatri: Studi Retrospektif pada Apotek di Bandung: Fakultas Farmasi Universitas Padjadjaran. Sumedang : Jurnal Farmasi Klinik Indonesia

. Kafeel, H., Rukh, R., Qamar, H., Bawany, J., Jamshed, M., Sheikh, R., Hanif, T., Bokhari,U.,Jawaid,W.,Javed,Y.danSaleem,Y.M., (2014). Possibility of Drug-Drug Interaction in Prescription Dispensed by Community and Hospital Pharmacy. Pharmacology & Pharmacy.




DOI: https://doi.org/10.37311/jsscr.v5i2.18042

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