Uji Aktivitas Antioksidan Ekstrak Etanol Umbi Keladi Tikus (Typhonium Flagelliforme (L.) Blume)

Elvira Santi, Andi Juaella Yustisi, Nurfitria Junita

Abstract


Rodent tuber (Typhonium flagelliforme (L.) Blume) is a medicinal plant used by the community as a drug. This plant is nutritious because one of chemical contents is triterpenoid which is having a role as the free radical scavenger that can lead to degenerative diseases. The aim of the research is to determine the extract antioxidant activities of rodent tuber (Typhonium flagelliforme (L.) Blume) based on the binding of free radicals of 1,1-diphenyl-2-picrylhydrazyl. Extract of rodent tuber (Typhonium flagelliforme (L.) Blume) was obtained by maceration method, the sample was macerated by using ethanol of 96%. This research used DPPH method. The antioxidant activity against free radical were measured by mean of UV-Vis spectrophotometry at a wavelength of 516 nm and calculated the value of IC50. The results showed that each rodent tuber extract (Typhonium flagelliforme (L.) Blume) has IC50 for the ethanol extract was 74.359 µ/mL and the comparison of quercetin with the value IC50 was 10.298 µg/mL respectively

Keywords


Rodent tuber (Typhonium flagelliforme (L.) Blume) is a medicinal plant used by the community as a drug. This plant is nutritious because one of chemical contents is triterpenoid which is having a role as the free radical scavenger that can lead to degener

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References


Backer,C.A. and Bakhuizen,R.C., 1963, Flora Of Java (Spermatopytes Only) Vol.1 Angiospermae, Families 111-160, Nordhoy-Groningen- The Netherlands.

Blois, M.S. 1958. Antioxidant Determinations By The Use of A Stable Free Radical. Journal Nature 181 (4617) : 1199- 1200

Budiyanto, A. 2015. Potensi Antioksidan, Inhibitor Tirosinase dan Nilai Toksisitas dari Beberapa Spesies Tanaman Mangrove di Indonesia. Bogor: Institut Pertanian Bogor.

Departemen Kesehatan Republik Indonesia., 1989, Materi Medika Indonesi Jilid VI, Departemen Kesehatan RI, Jakarta.

Departemen Kesehatan Republik Indonesia. 2008. Farmakope Herbal Indonesia.

Jakarta: Departemen Kesehatan Republik Indonesia.

Ditjen POM., 1979, Farmakope Indonesia Edisi III, Departemen Kesehatan Republik Indonesia, Jakarta.

Fitriansyah, S.N., Fidrianny, I. & Ruslan, K. 2017. Correlation of total phenolic, flavonoid and carotenoid content of Sesbania sesban (L.Merr) leaves extract with DPPH scavenging activities. International Journal of Pharmacognosy and Phytochemical Research. 9(1):89-94.

Erawati., 2012, Uji Aktivitas Antioksidan Ekstrak Daun Garcinia daedalanthera Pierre Dengan Metode DPPH (1,1-Difenil Pikril Hidrazil) dan Identifikasi Golongan Senyawa Kimia dari Fraksi Paling Aktif, Skripsi, Fakultas MIPA, Universitas Indonesia, Depok.

Hariana, A., 2008, Tumbuhan Obat dan Khasiatnya, Edisi kedua, Penebar Swadaya, Jakarta.

Hernani, R. M., 2005, Tanaman Berkhasiat Antioksidan, Penebar Swadya, Jakarta.

Katrin, E., 2012, Karakteristika dan Khasiat Keladi Tikus, ISSN, 8 (1):31-40.

Molyneux, P., 2004, The use of the stable free radicals diphenylpicrylhydrazyl (DPPH) for estimating antioxidant activity. Songklanakarin Journal of Science Technology, 26(2):211-219.

Ningtyas, R., 2010, ‘Uji Antioksidan dan Antibakteri Ekstrak Air Daun Kecombrang (Etlingera elatior (Jack) R.M. Smith) Sebagai Pengawet Alami Terhadap E.Coli dan Staphylococcus aureus’, Skripsi, S.Si., Fakultas MIPA, UIN Syarif Hidayatullah, Jakarta.

Nur Ikhlas. 2013. Uji Aktivitas Antioksidan Ekstrak Herba Kemangi (Ocimum

americanum Linn) dengan Metode DPPH (2,2-Difenil-1-Pikrilhidrazil). Jakarta: UIN Syarif Hidayatullah Jakarta.

Phongpaichit, S., Nikom, J., Rungjindamai, N., Sakayaroj, J., Towatana, H, N., Rukachaisirikul, V., and Kirtikara, K., 2007, Biological Activities of Extracts From Endophytic Fungi Isolated From Garcinia Plants. Immunology & Medical Microbiology, 51:517-525.

Putra, A., Tjahjono., Winarto., 2012, ‘Efektivitas Ekstrak Umbi Typhonium flagelliforme Fraksi Diklorometanolik dalam Menghambat Proliferasi Sel MCF-7 Kanker Payudara’, Skripsi, S.Ked ., Fakultas Kedokteran, Universitas Diponegoro, Semarang.

Putri, R.R., R.F. Hakim, dan S. Rezeki. 2017. Pengaruh Ekstrak Daun Tapak Dara

(Catharanthus roseus) terhadap Jumlah Fibroblas pada Proses Penyembuhan Luka diMukosa Oral. Journal Caninus Denstistry.

Suhaling Sukmawati. 2010. Uji aktivitas antioksidan Ekstrak Metanol Kacang Merah (Phaseolus vulgaris L) Dengan Metode DPPH. UIN Alaudin Makassar.

Suhartono, E., 2002, Oxygen toxicity by radiation and effect of glutamic piruvat transamine (GPT) activity rat plasma after vitamin C treatmen, International seminar on Environmental Chemistry and Toxicology, Yogyakarta.

Sulandi, A. 2013. Aktivitas Antioksidan Ekstrak Kloroform Buah Lakum (Cayratiatrifolia) dengan Metode DPPH (2,2-Difenil-1-pikrilhidrazil). Naskah Publikasi.Pontianak: Program Studi Farmasi Fakultas Kedokteran Universitas

Tanjungpura. 11 Desember.

Sukardi., 2011, Identifikasi dan Karakterisasi Umbi Keladi Tikus Sebagai Zat Antioksidan Alami, Gamma, 6:143-151.

Sunami, T., 2002, Aktivitas Antioksidan Penangkap Radikal Bebas Beberapa kecambah dari Biji Tanaman Familia Papilionaceae, Jurnal Farmasi Indonesia 2, 2:53-61.

Tilaar, M., 2012, The Power of Jamu Kekayaan dan Kearifan Lokal Indonesia, Kompas Gramedia, Jakarta.




DOI: https://doi.org/10.37311/jsscr.v5i1.18573

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