Potensi Ekstrak Biji Pala (Myristica fragrans L) Terhadap Penyembuhan Luka Bakar pada Mencit (Mus musculus)

Widy Susanti Abdulkadir, Endah Nurrohwinta Djuwarno, Dizky Ramadani Putri Papeo, Zulkarnain Marhaba

Abstract


The Nutmeg Plant (Myristica Fragrans L) is one of the spices plants empirically used as a therapeutic option for injury healing. Burn injury is damage to the skin's integrity caused by contact with a source with a high-temperature difference. This research aimed to determine the effectiveness of Nutmeg (Myristica Fragrans L) Seed extract on burn injury healing in Male Mice (Mus Musculus). Extraction was carried out through Maceration with Methanol solvent. Eighteen mice were divided into 6 groups: negative control (Na-CMC), positive control (Bioplacenton), and treatment groups with concentrations of 3%, 5%, 7%, and 10%. Burn injury was created using a 2 cm x 2 cm iron plate on the mice's back, and the healing of the burn injury diameter was observed from day 1 to day 20, with observation intervals at day 5, 10, 15, and 20. The data were analyzed using one-way ANOVA followed by an LSD test to determine the differences between test groups. The resalts indicate that the ethanol extract of Nutmeg (Myristica Fragrans L) see haseng effect on burn injury, with the most effective concentration being the extraet onoration of 10%, with a burn injury healing rate of up to 89,15%.

Keywords


Extract; Nutmeg (Myristica Fragrans L) seed, Burn Injury; Effectiveness

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References


. Sjamsuhidajat R, De Jong W,. 1997. Buku Ajar Ilmu Bedah. Jakarta: Penerbit Buku Kedokteran EGC.

. Bone, K., & Mills, S. (2013). Principles and Practice of Phytotherapy Second. Edition. Churchill Livingstone. Elsevier. New York

. Cho J.Y., Choi G.J., Son S.W., et al., (2007). Isolation and antifungal activity of lignans from Myristica fragrans against various plant pathogenic fungi, Pest Manag Sci, 63, pp. 935–940.

. Desiyana, L. S., Husni, M. A dan Zhafira, S. (2016). Uji Efektivitas Sediaan Gel fraksi Etil Asetat Daun Jambu Biji (Psidium guajava Linn.) Terhadap Penyembuhan Luka Tterbuka Pada Mencit (Mus musculus). Jurnal Natural. Vol 16(2) : 23-32.

. Dewi. Prastiana. S., 2010. Perbedaan Efek Pemberian Lendir Bekicot (Achantina fulica) dan Gel Bioplacenton Terhadap Penyembuhan Luka Bersih Pada Tikus Putih [Skripsi]. Fakultas Kedokteran, Universitas Sebelas Maret.

. Diki P. Wibowo, Yessi Febriani, Hesti Riasari, Diah L. Aulifa. 2018. Essential Oil Composition, Antioxidant and Antibacterial Activities of Nutmeg (Myristica fragrans Houtt) From Garut West Java. Indonesian Journal of Pharmaceutical Science and Technology. Bandung : UNPAD

. Eva Septerina Dwi Hapsari, Happy Indri Hapsari, Christiani Bumi Pangesti. 2017. Efektifitas Pemberian Ekstrak Biji Pala (Myristica fragrans) Dalam Penyembuhan Luka. Surakarta : STIKES Kusuma Husada Surakarta.

. Harborne, J.B., 1987, Metode Fitokimia Penuntun Cara Modern Menganalisis. Tumbuhan, Diterjemahkan oleh Kosasih Padmawinata dan Imam Sudiro,. Edisi 2. Bandung : ITB.

. Nurul Inayah, Rachmawati Ningsih, Tri Kustono Adi. 2012. Uji Toksisitas dan Identifikasi Awal Golongan Senyawa Aktif Ekstrak Etanol dan N-heksana Teripang Pasir (Holothuria scabra) kering Pantai Kenjeran Surabaya. J Alchemy. Volume 2 No 1

. Praisia M. E. Rumopa, Henoch Awaloei , Christi Mambo. 2016. Uji daya hambat ekstrak biji pala (myristicae fragrans) terhadap pertumbuhan bakteri staphylococcus aureus dan streptococcus pyogenes. Jurnal e-Biomedik (eBm), . Volume 4, Nomor 2

. Revi, Y., Ria, A dan Linda, A. 2011. Formulasi Krim Estrak Daun Kirinyuh (Euphatorium odoratum L) untuk Penyembuhan Luka.Jurnal Kesehatan Pharma Medika. Vol 3(1) : 229.

. Robinson T., 1995. Kandungan Organik Tumbuhan Tinggi. Bandung: Institut Teknologi Bandung,

. Srivikaya R.W.Ollu, Putri Pandarangga, Nemay A. Ndaong. 2019. Persembuhan luka incisi kulit mencit (Mus musculus) dengan pemberian ekstrak etanol teripang getah (Holothuria leucospilota). Jurnal Veterinel Nasional. Vol. 2 No. 1

. Suhirman S., dan Balitro, 2013. Diversifikasi Produk Biji Pala, Warta Penelitian dan Pengembangan Tanaman Industri. Vol 19 (3), hal. 17-20.

. Tiwari, Kumar, Kaur Mandeep, Kaur Gurpreet & Kaur Harleem. 2011. Phytochemical Screening and Extraction: A Review. Internationale Pharmaceutica Sciencia vol. 1: issue 1.

. Wijaya, B.A. Citraningtyas, G. dan Wehantouw, F. 2014. Potensi Ekstrak Etanol Tangkai Daun Talas (Colocasia esculenta [L]) Sebagai Alternatif Obat Luka Pada Kulit Kelinci (Oryctolagus cuniculus). Pharmacon. Jurnal Ilmiah Farmasi-UNSRAT. Volume 3. Nomor 3.

. Zhang, Y., Wu, X., Ren, Y., Fu, J., & Zhang, Y. 2004. Safety Evaluation of a Triterpenoid-Rich Extract from Bamboo Shavings. Food and Chemical toxicology 42 (11)




DOI: https://doi.org/10.37311/jsscr.v5i1.18996

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