Penapisan Fitokimia dan Efek Penyembuhan Luka Insisi Daun Jarak Merah (Jatropha gossypiifolia) pada Mencit (Mus musculus)

Abstract

Bellyache Bush (Jatropha gossypiifolia) is a plant registered as one of the plants withvarious medical properties due to its Flavonoids, Alkaloids, Tannins, and Terpenoids. Bellyache Bush plays a significant role in accelerating wound healing and cell regeneration. This research aims to determine the effectiveness of the ethyl acetate fraction from Bellyache Bush leaves (Jatropha gossypiifolia) on male mice (Mus musculus). Bellyache Bush leaves was extracted using a multistage maceration method using n-hexane and ethyl acetate as solvents. This effectiveness of incision wound healing was tested by divided the test animals into five experimental groups, and each consisting of 3 male mice. All mice were treated according to their respective experimental groups : Group 1 (negative control), Group 2 (positive control with 10% povidone iodine), Group 3 (5% Bellyache Bush extract), Group 4 (10% Bellyache Bush extract), Group 5 (15% Bellyache Bush extract), until the wounds healed or white scar tissue was observed. The results indicate that at a concentration of 15% the ethyl acetate fraction of Bellyache Bush extract was more effective compared to the positive control, povidine iodine.