1.png)
Aktivitas Kombinasi Krim Daun Pare (Momordica charantia L) dan Kulit Jeruk (Citrus nobilis) dalam Penyembuhan Luka Bakar
Abstract
Burns are injuries to the skin caused by heat, fire, hot steam, exposure to chemicals, solar radiation, or electric shock. Burns need to be treated immediately because they can cause infection in the skin. Healing burns can be done by utilizing several types of existing plants, namely bitter melon leaves and orange peels which are known to be able to help heal burns because they contain secondary metabolites such as flavonoids, tannins, saponins, steroids, alkaloids, and terpenoids which can be used for wound healing. The purpose of this study was to determine the effect of a combination of bitter melon leaf extract cream and orange peel as healing burns in white rats. This research is a quantitative study using laboratory experimental methods with a post test only control group design. In this study, male white rats were made with wounds on the back skin. Using 20 white rats divided into 5 different treatment groups. The negative control was given a cream base, the positive control was given Burnazin cream, F1 3% : 5%, F2 ie 4% : 4%, F3 ie 5% : 3%. The wound was smeared with preparations according to group division and carried out for 14 days. Based on the results of observations of the effect of a combination of bitter melon leaf extract and orange peel cream at F1 concentrations with a concentration ratio of 3%: 5%, it has a faster healing effect on burn area. Based on the results of the Kruskal wallis test on the healing of second degree burns in male white rats, there was a significant difference. The p value or sig is 0.014, so it can be concluded that there is a significant difference between the healing areas of burns in white rats.
Keywords
Full Text:
PDFReferences
Samsudin, Rahmawati Rinza, Anindita Riesti, and Retno Arimurti, ‘Potensi Ekstrak Kulit Jeruk Pacitan ( Citrus Sinensis ) Sebagai Stimulus Regenerasi Sel Pada Luka Bakar Rattus Norvegicus’, Jurnal Labora Medika, 2.2 (2018), 19–23
Rahmawati Rinza Samsudin, Anindita Riesti, And Retno Arimurti, ‘Potensi Ekstrak Kulit Jeruk Pacitan ( Citrus Sinensis ) Sebagai Stimulus Regenerasi Sel Pada Luka Bakar Rattus Norvegicus’, Jurnal Labora Medika, 2.2 (2018), 19–23.
Anderiani. (2019). Uji Aktifitas Anti Bakteri Sediaan Krim Ekstrak Etanol Kulit Buah Naga Daging Merah (Hylocereus Polyrhizus) Terhadap Propionibacterium Acnes Secra In Vitro. Fakultas Farmasi Dan Kesehatan Institut Kesehatan Helvetia, 47.
Anggowarsito, J. L. (2014). Luka Bakar Sudut Pandang Dermatologi. Jurnal Widya Medika, (2), 115–120. http://jurnal.wima.ac.id/index.php/JWM/article/view/852
Arifin, W. N., & Zahiruddin, W. M. (2017). Sample size calculation in animal studies using resource equation approach. Malaysian Journal of Medical Sciences, 24(5), 101–105. https://doi.org/10.21315/mjms2017.24.5.11
Aryati, Y. V. P., Setiawan, I., Ariani, N. R., & Hastuti, D. D. (2018). Pengaruh Gel Kombinasi Ekstrak Kulit Semangka ( Citrullus Lanatus( Thunb.)) Dan Ekstrak Kulit Manggis (Garcinia Mangostana L.) Terhadap Penyembuhan Luka Bakar Pada Kelinci. JPSCR : Journal of Pharmaceutical Science and Clinical Research, 3(2), 117. https://doi.org/10.20961/jpscr.v3i2.22534
Azizah, Z., & Widya Wati, S. (2018). Skrining Fitokimia Dan Penetapan Kadar Flavonoid Total Ekstrak Etanol Daun Pare (Momordica charantia L.). Jurnal Farmasi Higea, 10(2), 163.
Azkiya, Z., Ariyani, H., & Setia Nugraha, T. (2017). Evaluasi Sifat Fisik Krim Ekstrak Jahe Merah (Zingiber officinale Rosc. var. rubrum) Sebagai Anti Nyeri. Journal of Current Pharmaceutica Sciences, 1(1), 2598–2095.
Cahyaningsih, E., Megawati, F., & Artini, N. P. E. (2021). Uji Efektivitas Ekstrak Daun Pare (Momordica charantia L.) sebagai Bahan Pengawet Alami Buah Tomat. Jurnal Ilmiah Medicamento, 7(1), 41–46. https://doi.org/10.36733/medicamento.v7i1.1558
Cahyanta, A. N., Listina, O., & Chairunnisa, D. C. (2020). Aktivitas Antibakteri Kombinasi Ekstrak Daun Pepaya dan Kulit Jeruk Manis Terhadap Bakteri Propionibacterium acne Penyebab Jerawat Secara In-Vitro. Jurnal Politeknik Harapan Bersama Tegal, 9(1), 22–28.
Chairunnisa, S., Wartini, N. M., & Suhendra, L. (2019). Pengaruh Suhu dan Waktu Maserasi terhadap Karakteristik Ekstrak Daun Bidara (Ziziphus mauritiana L.) sebagai Sumber Saponin. Jurnal Rekayasa Dan Manajemen Agroindustri, 7(4), 551. https://doi.org/10.24843/jrma.2019.v07.i04.p07
Dewatisari, W. F., Rumiyanti, L., & Rakhmawati, I. (2018). Rendemen dan Skrining Fitokimia pada Ekstrak Daun Sanseviera sp. Jurnal Penelitian Pertanian Terapan, 17(3), 197. https://doi.org/10.25181/jppt.v17i3.336
Etebu, E., & Nwauzoma, A. B. (2014). A review on sweet orange (Citrus sinensis) health, diseases and management. American Journal of Research Communication, 2(2), 33–70. www.usa-journals.com
Fallo, E. . (2019). Formulasi Dan Uji Efektivitas Krim Kombinasi Ekstrak Kunyit Dan Lidah Buaya Terhadap Penyembuhan Luka Bakar , Program Studi Sarjana Farmasi Universitas Citra Bangsa Kupang 2019 .
Favela-Hernández, J. M. J., González-Santiago, O., Ramírez-Cabrera, M. A., Esquivel-Ferriño, P. C., & Camacho-Corona, M. D. R. (2016). Chemistry and pharmacology of Citrus sinensis. Molecules, 21(2). https://doi.org/10.3390/molecules21020247
Ghofroh. (2017). Uji Aktivitas Ekstrak Etanol 70% Daun Kitolod (Isotoma Longiflora) Terhadap Percepatan Penyembuhan Luka Bakar (Combustio) Derajat Ii A Pada Mencit (Mus Musculus).
Hariningsih, Y., & Hartono, A. (2022). Formulasi Krim Ekstrak Etanol Kulit Pisang Kepok (Musa Paradisiaca Formatypica) Sebagai Penyembuh Luka Bakar. Pengembangan Ilmu Dan Praktik Kesehatan, 1(2), 48–56. https://doi.org/10.56586/PIPK.V1I2.213
Juwita, A. P., Yamlean, P. V. Y., & Edy, H. J. (2013). Formulasi Krim Ekstrak Etanol Daun Lamun. Parmachon Jurnal Ilmiah Farmasi – UNSRAT, 2(02), 8–13.
Lumentut, N., Edi, H. J., & Rumondor, E. M. (2020). Formulasi dan Uji Stabilitas Fisik Sediaan Krim Ekstrak Etanol Kulit Buah Pisang Goroho (Musa acuminafe L.) Konsentrasi 12.5% Sebagai Tabir Surya. Jurnal MIPA, 9(2), 42. https://doi.org/10.35799/jmuo.9.2.2020.28248
Pazry, M., Busman, H., & Nurcahyani, N. (2017). Wound Healing Potential of an Ethanolic Extract of Bitter Melon Leaves (Momordica charantia L.) to Heal Back Injury on Male Mice (Mus musculus L.). Jurnal Penelitian Pertanian, 17(2), 109–116.
Putra, A., Kasdi, A., Pendidikan, W. S.-J. R., & 2019, undefined. (2019). Pengaruh Media Google Earth Terhadap Hasil Belajar Berdasarkan Keaktifan Siswa Kelas IV Tema Indahnya Negeriku di Sekolah Dasar. Journal.Unesa.Ac.Id, 5(3).
Rahmadhani, N., Yudaniayanti, I. S., Saputro, A. L., Triakoso, N., Wibawati, P. A., & Yudhana, A. (2020). Efektivitas Krim Ekstrak Buah Naga Merah (Hylocereus polyrhizus) dalam Meningkatkan Jumlah Sel Fibroblas Luka Bakar Derajat II pada Tikus Putih (Rattus norvegicus). Jurnal Medik Veteriner, 3(1), 65. https://doi.org/10.20473/jmv.vol3.iss1.2020.65-75
Rahimamullah M. Arsyad. (2022). Formulasi Dan Uji Efektivitas Salep Ekstrak Etanol Daun Talas (Colocasia Esculenta L.) Terhadap Penyembuhan Luka Bakar Derajat Ii Pada Kulit Tikus Putih Jantan Galur Wistar (Rattus Norvegicus).
Samsudin, R. R., Riesti, A., & Arimurti, R. (2018). Potensi Ekstrak Kulit Jeruk Pacitan ( Citrus Sinensis ) Sebagai Stimulus Regenerasi Sel Pada Luka Bakar Rattus Norvegicus. Jurnal Labora Medika, 2(2), 19–23.
Septiana, W. C., & Ardiaria, M. (2016). Efek Pemberian Seduhan Kulit Buah Naga Merah (Hylocereus Polyrhizus) Terhadap Kadar Malondialdehyde (Mda) Tikus Sprague Dawley Dislipidemia. Journal of Nutrition College, 5(4), 344–352. https://doi.org/10.14710/JNC.V5I4.16434
Tandi, J., Rizky, M., Mariani, R., Alan Program Studi, F. S., & STIFA Pelita Mas Palu, F. (2017). Uji Efek Ekstrak Etanol Daun Sukun (Artocarpus altilis (Parkinson Ex F.A.Zorn) Terhadap Penurunan Kadar Glukosa Darah, Kolesterol Total Dan Gambaran Histopatologi Pankreas Tikus Putih Jantan (Rattus norvegicus) Hiperkolesterolemia-Diabetes. Jurnal Sains Dan Kesehatan, 1(8), 384–396. https://doi.org/10.25026/JSK.V1I8.73
Triswanto Sentat, & Susiyanto Pangestu. (2016). View Of Uji Efek Analgesik Ekstrak Etanol Daun Kersen (Muntingia Calabura L.) Pada Mencit Putih Jantan (Mus Musculus) Dengan Induksi Nyeri Asam Asetat.
Tuloli, R., Edy, H. J., & Jayanto, I. (2020). Pharmacon-Program Studi Farmasi, Fmipa, Universitas Sam Ratulangi Formulasi Sediaan Krim Kombinasi Ekstrak Daun Seledri (Apium Graveolens L.) Dan Daun Jati (Tectona Grandis Linn.F) Sebagai Antibakteri Terhadap Staphylococcus Aureus. Cream Formulation Of C. 9, 1–9.
Wendersteyt, N. V., Wewengkang, D. S., & Abdullah, S. S. (2021). Uji Aktivitas Antimikroba Dari Ekstrak Dan Fraksi Ascidian Herdmania Momus Dari Perairan Pulau Bangka Likupang Terhadap Pertumbuhan Mikroba Staphylococcus Aureus, Salmonella Typhimurium Dan Candida Albicans. Pharmacon, 10(1), 706. Https://Doi.Org/10.35799/Pha.10.2021.32758
Zakiya, R., Mulqie, L., & Fitrianingsih, S. P. (2019). Uji Aktivitas Ekstrak Etanol Daun Kelor (Moringa oleifera Lam) Terhadap Penyembuhan Luka Bakar Derajat II pada Mencit Swiss Webster Jantan. Prosiding Farmasi, 5(2), 504–511.
DOI: https://doi.org/10.37311/jsscr.v5i2.21269
Refbacks
- There are currently no refbacks.
Copyright (c) 2023 Journal Syifa Sciences and Clinical Research
| EDITORIAL OFFICE OF JOURNAL SYIFA SCIENCES AND CLINICAL RESEARCH |
| Department of Pharmacy, Gorontalo State University Jl. Jenderal Sudirman No.6, Kota Gorontalo, Provinsi Gorontalo 96128, Indonesia |
| Email: info.jsscr@ung.ac.id Google Scholar : JOURNAL SYIFA SCIENCES AND CLINICAL RESEARCH |
