Analisis in Silico Pengaruh Kurkumin Terhadap Stabilitas Protein Frataxin

Anjas Wilapangga, Errol Rakhmad Noordam, Dian Yudianto, Nurfadilah Nurfadilah, Ela Amelia Ela Amelia, Apriyani Pramudiyawati Yunar, Desi Eka Putri

Abstract


Frataxin is a universally conserved protein in prokaryotes and eukaryotes, playing a crucial role in cellular iron homeostasis. This study aimed to evaluate the potential of curcumin, a bioactive compound derived from turmeric, to modulate the frataxin protein. Using molecular docking molegro virtual docker, we identified specific interactions between curcumin and amino acid residues Glu108, Asp112, and Glu111 on the frataxin protein. The hydrogen bonds formed between curcumin and these residues indicate a stable protein-ligand complex. These findings suggest that curcumin can specifically interact with frataxin and potentially modulate its function. This discovery paves the way for the development of novel curcumin-based therapies to address Friedreich's ataxia.

Keywords


Frataxin; Curcumin; Molecular Docking; in Silico

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DOI: https://doi.org/10.37311/jsscr.v7i1.29588

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