Polypharmacy and Potential Drug Interactions in Hospitalised Patients with Type 2 Diabetes Mellitus

Aries Meryta; Rahmat Widiyanto; Muhammad Fathan Nugrah Utama; Septia Wafa Khairiyah

doi:10.37311/jsscr.v7i2.33526

Polypharmacy and Potential Drug Interactions in Hospitalised Patients with Type 2 Diabetes Mellitus

Aries Meryta, Rahmat Widiyanto, Muhammad Fathan Nugrah Utama, Septia Wafa Khairiyah

Abstract

Diabetes mellitus is a prevalent chronic disease often accompanied by comorbidities that require multiple medications, increasing the risk of potential drug interactions. This study analysed the association between polypharmacy and potential drug interactions in hospitalised patients with type 2 diabetes mellitus at Kramat Jati Regional General Hospital. A retrospective cross-sectional study was conducted using medical records of 94 inpatients from October to December 2024. Potential drug interactions and their severity were assessed using Drugs.com, and statistical analysis was performed with the Chi-square test. Results showed that 93 patients (98.8%) experienced potential drug interactions, predominantly of moderate severity (82.5%). The most frequent interaction was between metformin and ranitidine. A significant association was observed between polypharmacy and potential drug interactions (p = 0.002). These findings highlight the importance of early detection and management of drug interactions in type 2 diabetes mellitus inpatients, with clinical pharmacists playing a crucial role in optimising therapy safety.

Keywords

Type 2 Diabetes Mellitus; Polypharmacy; Drug Interaction; Hospitalised Patients; Retrospective Study

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DOI: https://doi.org/10.37311/jsscr.v7i2.33526

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