Impact of Antituberculosis Medication Adherence on Quality of Life in Pulmonary TB Patients

Neni Ristiani; Eva Oktariani

doi:10.37311/jsscr.v7i2.33750

Impact of Antituberculosis Medication Adherence on Quality of Life in Pulmonary TB Patients

Neni Ristiani, Eva Oktariani

Abstract

Tuberculosis (TB) remains a major global public health problem, including in Indonesia. TB affects not only physical health but is also associated with psychological and social burdens, ultimately reducing patients’ quality of life. The quality of life of TB patients is strongly influenced by the treatment process, particularly adherence to antituberculosis drugs (OAT). The prolonged duration of TB treatment often challenges patients’ ability to remain adherent, despite its crucial role in recovery and prevention of drug resistance. This analytical observational study employed a cross-sectional design with total sampling and involved 37 pulmonary TB patients undergoing treatment at Pekanbaru City Health Centre, Indonesia. Data were collected using the MMAS-8 scale to assess medication adherence and the WHOQOL-BREF instrument to measure quality of life. Data analysis was performed using the Spearman correlation test. The results showed a significant relationship between adherence to antituberculosis medication and quality of life (p < 0.001, r = 0.572), indicating a moderate positive correlation. These findings underscore the importance of strengthening treatment adherence as a key strategy to improve clinical outcomes and enhance the overall well-being of TB patients. It is recommended that TB control programs integrate patient education, psychosocial support, and management of treatment-related burdens to sustain high adherence and optimize quality of life.

Keywords

Antituberculosis drugs; Medication adherence; Tuberculosis; Quality of life; MMAS-8; WHOQOL-BREF

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References

B. Gunadi, D. Saksono, Y. Pramono, and I. Agustina, Guidebook for Medical and Health Workers on Tuberculosis, Jakarta: Ministry of Health of the Republic of Indonesia, pp. 1–38, 2025. [Online]. Available: https://www.tbindonesia.or.id/wp-content/uploads/2025/01/Buku-Panduan-Tenaga-Medis-dan-Kesehatan-Tuberkulosis.pdf

World Health Organization, Report 20-23, vol. t/malaria/, no. March, 2023. [Online]. Available: https://www.who.int/teams/global-tuberculosis-programme/tb-reports

Ministry of Health, Republic of Indonesia, Indonesia Health Profile 2023, Jakarta: Ministry of Health, 2024. [Online]. Available: https://repository.kemkes.go.id/book/1276

Riau Provincial Health Office, Profil Kesehatan Provinsi Riau Tahun 2022, Pekanbaru: Dinas Kesehatan Provinsi Riau, 2022. [Online]. Available: https://dinkes.riau.go.id/sites/default/files/2023-11/Profil%20Kesehatan%20Provinsi%20Riau%202022.pdf

Pekanbaru City Government, Annual Accountability and Performance Report 2023, Government of Pekanbaru City, 2024. [Online]. Available: https://www.pekanbaru.go.id/p/data-transparansi/27-informasi-laporan-akuntabilitas-dan-kinerja-tahunan-pemerintah-daerah

T. Kastien-Hilka, B. Rosenkranz, M. Schwenkglenks, B. M. Bennett, and E. Sinanovic, “Association between health-related quality of life and medication adherence in pulmonary tuberculosis in South Africa,” Frontiers in Pharmacology, vol. 8, Dec. 2017. [Online]. Available: https://doi.org/10.3389/fphar.2017.00919

M. Megawati, R. S. A. W. Rinawati, and S. Soep, “The relationship of the medication adherence model to the quality of life of communities pulmonary tuberculosis suffering in the working area of the Muliorejo Health Center, Sunggal District, Deli Serdang 2023,” Jurnal Keperawatan, vol. 9, no. 1, pp. 26–42, 2024. [Online]. Available: https://doi.org/10.32668/jkep.v9i1.1467

B. Widjanarko, M. Gompelman, M. Dijkers, and M. J. van der Werf, “Factors that influence treatment adherence of tuberculosis patients living in Java, Indonesia,” Patient Preference and Adherence, vol. 3, pp. 231–238, 2009. [Online]. Available: https://doi.org/10.2147/PPA.S6020

Z. S. Nezenega, L. Perimal-Lewis, and A. J. Maeder, “Factors influencing patient adherence to tuberculosis treatment in Ethiopia: A literature review,” International Journal of Environmental Research and Public Health, vol. 17, no. 15, pp. 1–12, 2020. [Online]. Available: https://doi.org/10.3390/ijerph17155626

A. Barathi, Y. Krishnamoorthy, P. Sinha, C. Horsburgh, N. Hochberg, E. Johnson, et al., “Effect of treatment adherence on the association between sex and unfavourable treatment outcomes among tuberculosis patients in Puducherry, India: a mediation analysis,” Journal of Public Health (United Kingdom), vol. 45, no. 2, pp. 304–311, 2023. [Online]. Available: https://doi.org/10.1093/pubmed/fdac062

A. Lahdji, M. T. Anggraini, and A. Raynalda, “Education level and economic status in increasing adherence to medication in pulmonary tuberculosis patients,” Proceedings of the International Seminar on Community Health and Medical Sciences (ISOCMED), pp. 73–77, 2022. [Online]. Available: https://prosiding.unimus.ac.id/index.php/isocmed/article/view/1388

M. T. Patients and I. Adherence, Managing Tuberculosis Patients and Improving Adherence, Centers for Disease Control and Prevention, pp. 6–9, 2014. [Online]. Available: https://www.who.int/publications/i/item/9789240013131

A. Amalia, H. D. Arini, and M. Dhrik, “Analysis of the relationship of compliance rate of antituberculosis drug on the quality of life of lung tuberculosis patients,” Jurnal Ilmiah Mahaganesha, vol. 1, no. 2, pp. 67–74, Dec. 2022. [Online]. Available: https://ojs.farmasimahaganesha.ac.id/index.php/JIM/article/view/111

X. Chen, L. Du, R. Wu, J. Xu, H. Ji, Y. Zhang, et al., "The effects of family, society and national policy support on treatment adherence among newly diagnosed tuberculosis patients: A cross-sectional study," BMC Infectious Diseases, vol. 20, no. 1, pp. 1–11, 2020. [Online]. Available: https://doi.org/10.1186/s12879-020-05354-3

R. K. Yadav, H. P. Kaphle, D. K. Yadav, S. B. Marahatta, N. P. Shah, S. Baral, et al., "Health related quality of life and associated factors with medication adherence among tuberculosis patients in selected districts of Gandaki Province of Nepal," Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, vol. 23, p. 100235, 2021. [Online]. Available: https://doi.org/10.1016/j.jctube.2021.100235

S. A. Munro, S. A. Lewin, H. J. Smith, M. E. Engel, A. Fretheim, and J. Volmink, "Patient adherence to tuberculosis treatment: A systematic review of qualitative research," PLoS Medicine, vol. 4, no. 7, pp. 1230–1245, 2007. [Online]. Available: https://doi.org/10.1371/journal.pmed.0040238

DOI: https://doi.org/10.37311/jsscr.v7i2.33750

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