Studi Interaksi Obat Pasien Diabetes Melitus Tipe 2 dengan penyakit penyerta : Studi Kasus Rumah Sakit X Gorontalo

Abstract

Diabetes mellitus (DM) type 2 is a chronic disease caused by insulin that does not work properly or is called insulin resistance. Such a condition causes the emergence of DM comorbidities. The treatment of diabetes mellitus and comorbidities is based on the symptoms that appear, leading to polypharmacy and causing drug-related problems; one of which is drug interactions. This study aimed to determine the correlation between the number of drugs and the incidence of drug interactions. It employed non-experimental research with descriptive analysis design, retrospective data collection. The research sample that met the inclusion criteria consisted of 97 recipe. Further, data were then analyzed univariately using the chi-square test. The results showed the use of the drugs was glimepiride (31%), metformin (24%), insulin aspart + insulin detemir (13.5%), insulin aspart (13.5%), metformin + glimepirid (8%), insulin. + OHO (5%), insulin aspart + insulin glargine (2%), metformin + glibenclamide (1%), a combination of 2 insulin aspart (1%), and metformin + gliclazide (1%). Moreover, the number of drugs used by patients was 2-4 drugs (70%) and ≥5 drugs (30%). Drug interactions based on the mechanism of interaction are unknown (49%), pharmacodynamics (30%), and pharmacokinetics (21%). Drug interactions based on the degree of severity were moderate (76.23%), minor (23.13%), major (1.64%). There was a correlation between the number of drugs in one prescription and the incidence of drug interactions (P = 0.042 <0.05).