Pemanfaatan Rempah Tradisional Kunyit Kawasan Teluk Tomini Sebagai Vitamin Herbal dalam Pencegahan Jantung Pada Masyarakat Pentadu Barat, Kabupaten Boalemo, Provinsi Gorontalo

Teti Sutriyati Tuloli, Zulkifli B Pomalango, Mohamad Aprianto Paneo

Abstract


Aterosklerosis merupakan penyebab umum penyakit serebro-kardiovaskular dan merupakan kondisi pembuluh darah bisa kronis. Fungsi mekanistik kurkumin terhadap aterosklerosis sebagian disebabkan oleh efek anti-inflamasi dan anti-oksidatifnya serta penghambatan proliferasi dan migrasi sel otot polos pembuluh darah. Untuk itu, pengabdian dilaksanakan bertujuan untuk meningkatkan peran aktif masyarakat, dalam  program pencegahan penyakit jantung melalui pemanfaatan kunyit yang diolah menjadi serbuk minuman dan makanan. Metode pelaksanaan yang digunakan pada kegiatan ini terdiri atas dua bagian, yaitu Seminar dan Workshop. Seminar tentang pentingnya kunyit dalam menjaga kesehatan jantung disampaikan langsung oleh dosen pembimbing lapangan dan Workshop pembuatan suplemen herbal dipraktikan langsung oleh mahasiswa peserta KKN Profesi kesehatan didampingi langsung oleh dosen pembimbing lapangan serta pembuatan disaksikan langung oleh peserta undangan yang terdiri dari pemerintah desa dan masyarakat. Pembuatan produk herbal minuman herbal frape di praktikan langsung oleh tamu undangan kegiatan. Produk Puding dan Minuman herbal frappe mendapatkan respon positif pada saat disuguhkan kepada undangan. Respon berupa aroma, dan rasa yang baik,serta efek segar yang dirasakan pada saat dikonsumsi. Selain itu Kedua produk ini dapat meningkatkan kesehatan jantung khususnya untuk masyarakat yang bekerja sebagai di waktu cuaca ekstrim seperti nelayan yang merupakan mata pencaharian terbesar didesa pentadu barat, dan dinilai  dapat meningkatkan ekonomi desa, karena kedua produk suplemen herbal ini potensi untuk dijual serta dapat dimasukan dalam program peningkatan gizi masyarakat.  

Keywords


Aterosklerosis ; Penyakit Jantung, Kunyit; Suplemen Herbal; Desa Pentadu Barat

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References


Hannawi, S., Hannawi, H., & Al Salmi, I. (2020). Cardiovascular disease and subclinical atherosclerosis in rheumatoid arthritis). In Hypertension Research. https://doi.org/10.1038/s41440-020-0483-4

Bi, C., Fu, Y., & Li, B. (2020). Brain-derived neurotrophic factor alleviates diabetes mellitus-accelerated atherosclerosis by promoting M2 polarization of macrophages through repressing the STAT3 pathway. Cellular Signalling. https://doi.org/10.1016/j.cellsig.2020.109569

Ito, K., Maeda, T., Tada, K., Takahashi, K., Yasuno, T., Masutani, K., Mukoubara, S., Arima, H., & Nakashima, H. (2020). The role of cigarette smoking on new-onset of chronic kidney disease in a Japanese population without prior chronic kidney disease: Iki epidemiological study of atherosclerosis and chronic kidney disease (ISSA-CKD). Clinical and Experimental Nephrology.

B Miao, J., Zang, X., Cui, X., & Zhang, J. (2020). Autophagy, hyperlipidemia, and atherosclerosis. In Advances in Experimental Medicine and Biology. https://doi.org/10.1007/978-981-15-4272-5_18

Ye, J., Wang, Y., Wang, Z., Liu, L., Yang, Z., Wang, M., Xu, Y., Ye, D., Zhang, J., Zhou, Q., Lin, Y., Ji, Q., & Wan, J. (2020). The Expression of IL-12 Family Members in Patients with Hypertension and Its Association with the Occurrence of Carotid Atherosclerosis. Mediators of Inflammation. https://doi.org/10.1155/2020/2369279

Ntaios, G., Pearce, L. A., Meseguer, E., Endres, M., Amarenco, P., Ozturk, S., Lang, W., Bornstein, N. M., Molina, C. A., Pagola, J., Mundl, H., Berkowitz, S. D., Liu, Y. Y., Sen, S., Connolly, S. J., & Hart, R. G. (2019). Aortic Arch Atherosclerosis in Patients With Embolic Stroke of Undetermined Source: An Exploratory Analysis of the NAVIGATE ESUS Trial. Stroke. https://doi.org/10.1161/STROKEAHA.119.025813

Pomozova, T. P., Lykov, Y. V., Komarova, I. S., Dyatlov, N. V., & Zhelnov, V. V. (2019). Clinical and laboratory features of primary acute myocardial infarction in patients with obstructive and non-obstructive coronary atherosclerosis. Kardiologiya. https://doi.org/10.18087/cardio.2640

Yang, C. W., & Mousa, S. A. (2012). The effect of red yeast rice (Monascus purpureus) in dyslipidemia and other disorders. In Complementary Therapies in Medicine. https://doi.org/10.1016/j.ctim.2012.07.004

Chan, G. H. H., Law, B. Y. K., Chu, J. M. T., Yue, K. K. M., Jiang, Z. H., Lau, C. W., Huang, Y., Chan, S. W., Ying-Kit Yue, P., & Wong, R. N. S. (2013). Ginseng extracts restore high-glucose induced vascular dysfunctions by altering triglyceride metabolism and downregulation of atherosclerosis-related genes. Evidence-Based Complementary and Alternative Medicine. https://doi.org/10.1155/2013/797310

Kim, J. H., Yang, H. J., Kim, Y. J., Park, S., Lee, O. hee, Kim, K. S., & Kim, M. J. (2016). Korean turmeric is effective for dyslipidemia in human intervention study. Journal of Ethnic Foods. https://doi.org/10.1016/j.jef.2016.08.006

González-Ortega, L. A., Acosta-Osorio, A. A., Grube-Pagola, P., Palmeros-Exsome, C., Cano-Sarmiento, C., García-Varela, R., & García, H. S. (2020). Anti-inflammatory activity of curcumin in gel carriers on mice with atrial edema. Journal of Oleo Science. https://doi.org/10.5650/jos.ess19212

Song, H. C., Chen, Y., Chen, Y., Park, J., Zheng, M., Surh, Y. J., Kim, U. H., Park, J. W., Yu, R., Chung, H. T., & Joe, Y. (2020). GSK-3β inhibition by curcumin mitigates amyloidogenesis via TFEB activation and anti-oxidative activity in human neuroblastoma cells. Free Radical Research. https://doi.org/10.1080/10715762.2020.1791843

. Zhang, S., Zou, J., Li, P., Zheng, X., & Feng, D. (2018). Curcumin Protects against Atherosclerosis in Apolipoprotein E-Knockout Mice by Inhibiting Toll-like Receptor 4 Expression. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/acs.jafc.7b04260

Marchio, P., Guerra-Ojeda, S., Vila, J. M., Aldasoro, M., Victor, V. M., & Mauricio, M. D. (2019). Targeting early atherosclerosis: A focus on oxidative stress and inflammation. In Oxidative Medicine and Cellular Longevity. https://doi.org/10.1155/2019/8563845

Chen, Y. qing, Chai, Y. sen, Xie, K., Yu, F., Wang, C. jiang, Lin, S. hui, Yang, Y. zheng, & Xu, F. (2020). Curcumin Promotes the Expression of IL-35 by Regulating Regulatory T Cell Differentiation and Restrains Uncontrolled Inflammation and Lung Injury in Mice. Inflammation. https://doi.org/10.1007/s10753-020-01265-2

Xie, M., Tang, Q., Nie, J., Zhang, C., Zhou, X., Yu, S., Sun, J., Cheng, X., Dong, N., Hu, Y., & Chen, L. (2020). Bmal1-downregulation aggravates porphyromonas gingivalis-induced atherosclerosis by encouraging oxidative stress. Circulation Research. https://doi.org/10.1161/CIRCRESAHA.119.315502

Boström, K. I. (2016). Where do we stand on vascular calcification? In Vascular Pharmacology. https://doi.org/10.1016/j.vph.2016.05.014

Kattoor, A. J., Goel, A., & Mehta, J. L. (2019). LOX-1: Regulation, signaling and its role in atherosclerosis. In Antioxidants. https://doi.org/10.3390/antiox8070218

Salimi, A., Jamali, Z., & Shirmard, L. R. (2023). Curcumin for protecting mitochondria and downregulating inflammation. In Molecular Nutrition and Mitochondria. https://doi.org/10.1016/b978-0-323-90256-4.00014-x

Yamin, M, Ayu, D.F, dan Hamzah F. (2017). Lama Pengeringan terhadap Aktivitas Antioksidan dan Mutu Teh Herbal Daun Ketepeng Cina (Cassia alata L.). Jom Faperta. Vol. 4. No. 2. 2017. Hal 9-12




DOI: https://doi.org/10.37905/phar.soc.v2i3.21597

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