PERBEDAAN MPV (MEAN PLATELET VOLUME) PADA PASIEN KARSINOMA MAMMAE METASTASIS DAN NON METASTASIS PASCA KEMOTERAPI

Bryan Joe Christiantra Filus, Haerani Harun, Alfa Gilbert Ezra Koroh, Rahma Badaruddin, Nilawati Nilawati, Asrawati Sofyan, Rahma Rahma, Almaida Taurisa

Abstract


Karsinoma mammae merupakan keganasan yang paling sering didiagnosis pada perempuan secara global dan menjadi salah satu penyebab utama kematian akibat kanker. Penelitian terdahulu mengenai hubungan Mean Platelet Volume (MPV) dengan karsinoma mammae menunjukkan hasil yang beragam, dan penelitian yang membandingkan nilai MPV berdasarkan status metastasis pada pasien yang telah menjalani kemoterapi masih terbatas. Kebaruan penelitian ini terletak pada perbandingan nilai MPV antara pasien karsinoma mammae metastasis dan nonmetastasis pada populasi pascakemoterapi berdasarkan data rekam medis. Penelitian ini bertujuan untuk menganalisis perbedaan nilai MPV berdasarkan status metastasis. Penelitian menggunakan desain observasional analitik komparatif dengan pendekatan cross-sectional di RS Anutapura Palu menggunakan data rekam medis periode 2025–2026. Sebanyak 140 pasien dipilih menggunakan teknik total sampling berdasarkan kriteria inklusi dan eksklusi. Sampel terdiri atas pasien karsinoma mammae yang telah menjalani kemoterapi serta memiliki data nilai MPV dan status metastasis yang dapat dievaluasi. Parameter yang dianalisis meliputi nilai MPV dan status metastasis. Analisis dilakukan secara univariat dan bivariat menggunakan uji Mann–Whitney U dengan tingkat kemaknaan p < 0,05. Hasil penelitian menunjukkan median MPV sebesar 9 fL pada kelompok metastasis maupun nonmetastasis, dengan p-value sebesar 0,762 (p > 0,05), sehingga tidak terdapat perbedaan nilai MPV yang bermakna secara statistik antara kedua kelompok. Hasil ini menunjukkan bahwa pada sampel penelitian, status metastasis pada pasien karsinoma mammae pascakemoterapi tidak berkaitan dengan perbedaan nilai MPV bermakna secara statistik. Dengan demikian, MPV belum dapat dipertimbangkan sebagai parameter tunggal untuk membedakan status metastasis pada populasi penelitian dan penggunaannya perlu dipertimbangkan bersama parameter klinis, laboratoris, serta pemeriksaan penunjang lainnya.

Keywords


Carcinoma Mammae; Carcinoma Mammae Metastasis; MPV

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References


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DOI: https://doi.org/10.35971/gojhes.v10i4.40873

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