Bioaktivitas Ekstrak Daun Namnam (Cynometra cauliflora L.) Terhadap Antidiabetes Secara In Vitro

Syarah Anliza, Nurmeily Rachmawati

Abstract


Every day our bodies produce free radicals and every organism has a natural defense system to reduce free radicals. In a healthy state the amount of antioxidants in the body can balancing the amount of free radicals. However, in certain circumstances it can interfere with the body's defense against free radicals. This situation underlies the occurrence of various diseases caused by radicals, one of which is non-communicable (degenerative) diseases. Many therapies are available for the treatment of diabetes, do not completely cure the disease but cause many side effects. Namnam plant is predict to have the ability as an anti-diabetic agent. The purpose of this study was to determine the in vitro bioactivity of Namnam leaves extract against antidiabetic. This research conducted extraction, phytochemical test, total phenol test, total flavonoid test, and in vitro -glucosidase enzyme inhibition test as an antidiabetic. The results of the study showed that the ethanol extract produced secondary metabolites, namely flavonoids and steroids. The results of the α-glucosidase inhibition test resulted in an IC50 value of 30,89 ppm. The comparison that has been used is acarbose which produces IC50 of 0.22 ppm. Ethanol extract and ethyl acetate extract have inhibitory ability due to the presence of flavonoid and steroid compounds contained in the extract

Keywords


namnam leaves; ethanol extract; α-glucosidase

Full Text:

PDF

References


Anliza, S., & Rachmawati, N. (2021). Cytotoxic Activity of Ethanol Extract in Namnam Leaves (cynometra cauliflora l.) to Hela Cell | Anliza | Walisongo Journal of Chemistry. Walisongo Journal of Chemistry, 4(2), 107-112. https://journal.walisongo.ac.id/index.php/wjc/article/view/7999/3690

Aziz, A., & Iqbal, M. (2013). Antioxidant activity and phytochemical composition of Cynometra cauliflora. Journal of Experimental and Integrative Medicine, 3(4), 337. https://doi.org/10.5455/jeim.250813.or.086

Badan Penelitian dan Pengembangan Kesehatan. (2018). Laporan_Nasional_Riskesdas2018_FINAL.pdf. In Badan Penelitian dan Pengembangan Kesehatan (p. 198). http://labdata.litbang.kemkes.go.id/images/download/laporan/RKD/2018/Laporan_Nasional_RKD2018_FINAL.pdf

Dompeipen, E. J., & Simanjuntak, D. P. (2015). AKTIVITAS ANTIDIABETES DAN ANTIOKSIDAN KAPANG ENDOFIT DARI TANAMAN MAHONI (Swietenia macrophylla King) (Antidiabetic and Antioxidant Activity of Endophytic Fungi from Mahogoni Plant (Swietenia macrophylla King)). Biopropal Industri, 6(1), 7-17.

Fatmawati, Susilawati, Oswari, L. D., Fadiya, & Nadya. (2021). Uji Aktivitas Penghambatan Enzim ï¡ -glucosidase Ekstrak Air dan Ekstrak Etanol Kayu Kuning ( Arcangelisia flava ). Jurnal Kedokteran Dan Kesehatan Publikasi Ilmiah, 8(1), 53-60.

Febrinda, A. E., Astawan, M., Wresdiyati, T., & D, Y. N. (2013). View of KAPASITAS ANTIOKSIDAN DAN INHIBITOR ALFA GLUKOSIDASE EKSTRAK UMBI BAWANG DAYAK [Antioxidant and Alpha-Glucosidase Inhibitory Properties of Bawang Dayak Bulb Extracts]. Journal IPB, 24(2), 161-167. https://doi.org/https://doi.org/10.6066/jtip.2013.24.2.161

Gazali, M., Nafus, H., Nurjnah, & Zuriat. (2019). EKSPLORASI SENYAWA BIOAKTIF EKSTRAK DAUN NIPAH ( Nypa fruticans Wurmb ) ASAL PESISIR ACEH BARAT SEBAGAI ANTIOKSIDAN ( Nypa Fruticans Wurmb ) from The Coast of West Aceh as Antioxidant. Jurnal Pengolahan Hasil Perikanan Indonesia, 22(1), 155-163.

Jini, D., & Sharmila, S. (2020). Green synthesis of silver nanoparticles from Allium cepa and its in vitro antidiabetic activity. Materials Today: Proceedings, 22(xxxx), 432-438. https://doi.org/10.1016/j.matpr.2019.07.672

Kusuma, A. S. W. (2015). The Effect of Ethanol Extract of Soursop Leaves (Annona muricata L.) to Decreased Levels of Malondialdehyde. Jurnal Majority, 4(3), 14-18.

Laila Febgriantie., Ani Rosita., dan A. D. (2017). GLOBAL HEALTH SCIENCE , Volume 2 Issue 4 , Desember 2017 ISSN 2503-5088 GLOBAL HEALTH SCIENCE ----- http://jurnal.csdforum.com/index.php/ghs GLOBAL HEALTH SCIENCE , Volume 2 Issue 4 , Desember 2017 ISSN 2503-5088 GLOBAL HEALTH SCIENCE ----- http://jurnal. Global Health Science, 2(2), 325-331. http://jurnal.csdforum.com/index.php/GHS/article/view/160

Lantah, P. L., Montolalu, L. A., & Reo, A. R. (2017). KANDUNGAN FITOKIMIA DAN AKTIVITAS ANTIOKSIDAN EKSTRAK METANOL RUMPUT LAUT Kappaphycus alvarezii. Media Teknologi Hasil Perikanan, 5(3), 73-79. https://ejournal.unsrat.ac.id/index.php/jmthp/article/view/16785

Lestari, D. M., Mahmudati, N., Sukarsono, S., Nurwidodo, N., & Husamah, H. (2018). Aktivitas Antioksidan Ekstrak Fenol Daun Gayam (Inocarpus fagiferus Fosb). Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal, 35(1), 37-43. https://doi.org/10.20884/1.mib.2018.35.1.596

Ode Sumarlin, L. A., Sukandar, D., & Pratiwi, D. L. (2019). Aktivitas Penghambatan α-Glukosidase Campuran Ekstrak Daun Namnam (Cynometra cauliflora L.) dan Madu Kaliandra. Al-Kimiya: Jurnal Ilmu Kimia Dan Terapan, 6(2), 87-94. https://journal.uinsgd.ac.id/index.php/ak/article/view/6577

Putri, W. S., Warditiani, N. K., & Larasanty, L P, F. (2015). SKRINING FITOKIMIA EKSTRAK ETIL ASETAT KULIT BUAH MANGGIS (Garcinia mangostana L.). Jurnal Farmasi Udayana, 17(2), 56-60. https://ojs.unud.ac.id/index.php/jfu/article/view/8405/6271

Seo, S.-Y., Sancheti, S., & Sancheti, S. (2009). Chaenomeles Sinensis: A Potent α-and β-Glucosidase Inhibitor. American Journal of Pharmacology and Toxicology, 4(1), 8-11.

Syafitri, N. E., Bintang, M., & Falah, S. (2014). Current Biochemistry CURRENT BIOCHEMISTRY Kandungan Fitokimia, Total Fenol, dan Total Flavonoid Ekstrak Buah Harendong (Melastoma affine D. Don). Current Biochemistry, 1(3), 105-115.

Wahyuni, W. T., Darusman, L. K., Pitria, P., & Rahmat, A. (2018). ANALISIS KADAR FLAVONOID DAN ANTIOKSIDAN EKSTRAK DAUN KENIKIR (Cosmos caudatus), RUMPUT MUTIARA (Oldenlandia corymbosa), DAN SIRSAK (Annona muricata) DENGAN TEKNIK SPEKTROMETRI. Analit: Analytical and Environmental Chemistry, 3(1), 38-46. https://doi.org/10.23960/AEC.V3.I1.2018.P38-46

Yuda, I. P., Aryenti, A., & Juniarti, J. (2018). Aktivitas Inhibitor ÃŽ±-Glukosidase Ekstrak Daun Toona sureni (Bl. ) Merr. sebagai Antihiperglikemik. Majalah Kesehatan Pharmamedika, 10(2), 063-070. https://academicjournal.yarsi.ac.id/index.php/majalah-Pharamedika/article/view/724




DOI: https://doi.org/10.37905/jambchem.v6i2.13379

Refbacks

  • There are currently no refbacks.


Copyright (c) 2024 Jambura Journal of Chemistry



EDITORIAL OFFICE

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.