Alvian Mohamad Yapanto, Khairani Ayu Lestari, Halin Aliyyu, Eldita Luthfia Tumeko, Shella Setiani, Sandhia Aidhitya, Rika Ferlianti


Preeclampsia, a pregnancy-related syndrome impacting multiple organ systems, is a leading cause of maternal mortality, bleeding, and infection. The World Health Organization estimates that preeclampsia contributes to 70,000 maternal and 500,000 infant deaths annually worldwide. Recent research highlights the importance of optimal nutrition from preconception through childhood and adolescence. The novelty of this research is that it examines the relationship between preeclampsia and food: a comprehensive literature review of maternal health. This literature review collected and analyzed articles from online databases to explore the role of micronutrient supplementation in preventing preeclampsia. Findings emphasize the potential benefits of micronutrient supplementation, including L-arginine, vitamin D, and folic acid. Recommendations include daily vitamin D supplementation of 10-25 µg for pregnant women, oral administration of 3g per day of L-arginine for 3 weeks, and high-dose folic acid (4 mg/day) during the first trimester of pregnancy along with multivitamin supplementation. Micronutrient supplements and consuming nutrient-rich foods during pregnancy have been proposed to reduce the likelihood of developing preeclampsia. These approaches can potentially impact the formation of the placenta, oxidative stress levels, and the expression of angiogenic factors. This review underscores the importance of optimal nutrition throughout preconception, pregnancy, birth, and beyond for maternal and infant health. It highlights the need for further research and policy attention in this area. Implementing recommended micronutrient supplementation strategies during pregnancy may contribute to improved maternal and infant outcomes and should be considered as part of a comprehensive prenatal care program.


L-arginine; Maternal mortality; Micronutrient supplementation; Preeclampsia; Vitamin D.

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Fajriyani FK, Pamungkasari EP, Murti B. Effect of Vitamin D Supplementation and Calcium in Reducing the Risk of Preeclampsia: Meta-Analysis. Indones J Med. 2020;5(4):308–20.

Primayanti I, Ario Danianto, Rizkinov Jumsa, NN Geriputri, Marie Yuni Andari. Gambaran Epidemiologi Faktor Risiko Preeklamsia Pada Ibu Hamil. Unram Med J. 2022;11(1):785–8.

Yang Y, Le Ray I, Zhu J, Zhang J, Hua J, Reilly M. Preeclampsia Prevalence, Risk Factors, and Pregnancy Outcomes in Sweden and China. JAMA Netw Open. 2021;4(5):1–14.

Cunningham FG, Leveno KJ, Bloom SL, Spong CY, Dashe JS, Hoffman BL, et al. Williams Obstetrics 24th Edition. McGraw-Hill Education. 2014. 100- p.

Belay AS, Wudad T. Prevalence and associated factors of pre-eclampsia among pregnant women attending anti-natal care at Mettu Karl referal hospital, Ethiopia: cross-sectional study. Clin Hypertens. 2019;25(1):1–8.

Rana S, Lemoine E, Granger J, Karumanchi SA. Preeclampsia: Pathophysiology, Challenges, and Perspectives. Circ Res. 2019;124(7):1094–112.

Yushida Y, Zahara E. The risk factors toward preeclampsia events of pregnant women in meureubo and johan pahlawan community health center west aceh. Open Access Maced J Med Sci. 2020;8(E):670–3.

American College of Obstetricians and Gynecologists. Gestational Hypertension and Preeclampsia. ACOG Pract Bull. 2020;135(6):e237–60.

Setyorini D, Santoso B, Martini S, Ernawati. Risk Factors of Preeclampsia and Eclampsia in Surabaya. Dama Int J Res. 2017;2(7):63–6.

Vousden N, Lawley E, Seed PT, Gidiri MF, Goudar S, Sandall J, et al. Incidence of eclampsia and related complications across 10 low-and middlere source geographical regions: Secondary analysis of a cluster randomised controlled trial. PLoS Med. 2019;16(3):1–15.

Marshall NE, Abrams B, Barbour LA, Christian P, Friedman JE, Jr WWH, et al. The Importance of Nutrition in Pregnancy and Lactation: Lifelong Consequences. Am J Obs Gynecol. 2022;226(5):607–32.

Achamrah N, Ditisheim A. Nutritional approach to preeclampsia prevention. Curr Opin Clin Nutr Metab Care. 2018;21(3):168–73.

Perry A, Stephanou A, Rayman MP. Dietary factors that affect the risk of pre-eclampsia. BMJ Nutr Prev Heal. 2022;5(1):118–33.

Grum T, Hintsa S, Hagos G. Dietary factors associated with preeclampsia or eclampsia among women in delivery care services in Addis Ababa, Ethiopia: A case control study 11 Medical and Health Sciences 1114 Paediatrics and Reproductive Medicine 11 Medical and Health Sciences 1117 Public Health and Health Services. BMC Res Notes. 2018;11(1):1–5.

August P, Sibai BM. Preeclampsia: Clinical Features and Diagnosis. UpToDate. 2022;1–42.

Behjat Sasan S, Zandvakili F, Soufizadeh N, Baybordi E. The Effects of Vitamin D Supplement on Prevention of Recurrence of Preeclampsia in Pregnant Women with a History of Preeclampsia. Obstet Gynecol Int. 2017;2017.

Purswani JM, Gala P, Dwarkanath P, Larkin HM, Kurpad A, Mehta S. The role of vitamin D in pre-eclampsia: A systematic review. BMC Pregnancy Childbirth. 2017;17(1):1–15.

Dahma G, Neamtu R, Nitu R, Gluhovschi A, Bratosin F, Grigoras ML, et al. The Influence of Maternal Vitamin D Supplementation in Pregnancies Associated with Preeclampsia: A Case-Control Study. Nutrients. 2022;14(15).

Raia-Barjat T, Sarkis C, Rancon F, Thibaudin L, Gris JC, Alfaidy N, et al. Vitamin D deficiency during late pregnancy mediates placenta-associated complications. Sci Rep. 2021;11(1):1–9.

Fogacci S, Fogacci F, Banach M, Michos ED, Hernandez A V., Lip GYH, et al. Vitamin D supplementation and incident preeclampsia: A systematic review and meta-analysis of randomized clinical trials. Clin Nutr. 2020;39(6):1742–52.

Kasanova E. Calcium Consumption to Prevent Preeclampsia. J Surya Med. 2022;8(1):29-36]].

Goto E. Effects of prenatal oral l-arginine on birth outcomes: a meta-analysis. Sci Rep. 2021;11(1):1–10.

Weckman AM, McDonald CR, Baxter JAB, Fawzi WW, Conroy AL, Kain KC. Perspective: L-arginine and L-citrulline Supplementation in Pregnancy: A Potential Strategy to Improve Birth Outcomes in Low-Resource Settings. Adv Nutr. 2019;10(5):765–77.

Hsu CN, Tain YL. Impact of arginine nutrition and metabolism during pregnancy on offspring outcomes. Nutrients. 2019;11(7):1–15.

Darling A, McDonald CR, Urassa WS, Kain KC, Mwiru RS, Fawzi WW. Maternal dietary L-arginine and adverse birth outcomes in Dar es Salaam, Tanzania. Am J Epidemiol. 2017;186(5):603–11.

Tashie W, Fondjo LA, Owiredu WKBA, Ephraim RKD, Asare L, Adu-Gyamfi EA, et al. Altered bioavailability of nitric oxide and L-arginine is a key determinant of endothelial dysfunction in preeclampsia. Biomed Res Int. 2020;2020.

Camarena Pulido EE, García Benavides L, Panduro Barón JG, Pascoe Gonzalez S, Madrigal Saray AJ, García Padilla FE, et al. Efficacy of L-arginine for preventing preeclampsia in high-risk pregnancies: A double-blind, randomized, clinical trial. Hypertens Pregnancy. 2016;35(2):217–25.

Zheng J, Huang M, Huang Q, Chen Q, Chen Z. The relationship between fetuin-A and coronary atherosclerotic heart disease (CHD) and CHD-related risk factors: A retrospective study. Medicine (Baltimore). 2021 Oct;100(43):e27481.

Liu S, Tao S, Tan J, Hu X, Liu H, Li Z. Long-term follow-up of fibular graft for the reconstruction of bone defects. Med (United States). 2018;97(40):1–8.

Alvestad S, Husebye ESN, Christensen J, Dreier JW, Sun Y, Igland J, et al. Folic Acid and Risk of Preterm Birth, Preeclampsia, and Fetal Growth Restriction among Women with Epilepsy: A Prospective Cohort Study. Neurology. 2022;99(6):E605–15.

Sayyah-Melli M, Ghorbanihaghjo A, Alizadeh M, Kazemi-Shishvan M, Ghojazadeh M, Bidadi S. The effect of high dose folic acid throughout pregnancy on homocysteine (Hcy) concentration and pre-eclampsia: A randomized clinical trial. PLoS One. 2016;11(5):1–11.

Zhao ZW, Lin CG, Wu LZ, Luo YK, Fan L, Dong XF, et al. Serum fetuin-A levels are associated with the presence and severity of coronary artery disease in patients with type 2 diabetes. Biomarkers. 2013 Mar;18(2):160–4.

Wang Y, Zhao N, Qiu J, He X, Zhou M, Cui H, et al. Folic Acid Supplementation and Dietary Folate Intake, and Risk of Preeclampsia. Eur J Clin Nutr. 2015;69(10):1145–50.

Li Z, Ye R, Zhang L, Li H, Liu J, Ren A. Folic acid supplementation during early pregnancy and the risk of gestational hypertension and preeclampsia. Hypertension. 2013;61(4):873–9.

Wen SW, Champagne J, Rennicks White R, Coyle D, Fraser W, Smith G, et al. Effect of folic acid supplementation in pregnancy on preeclampsia: The folic acid clinical trial study. J Pregnancy. 2013;2013.

DOI: https://doi.org/10.35971/jjhsr.v5i3.19470


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