1.png)
Edge Activator: Effect of Concentration Variation of Tween 80 on Characteristics and Rate of Difusion transfersome sodium diclofenac
Abstract
Diclofenac sodium is a Transfersom is a transdermal delivery system consisting of phospholipids and edge activators. Transfersom increases the size of the stratum corneum lipid barrier pores, then enters the skin through the drive of the trans-barrier motion and squeezes itself to follow the lipid barrier pore size. The purpose of this study is to determine the effect of the tween-80 concentration as an edge activator on the characteristics and diffusion rate of diclofenac sodium transfersom. Transferom preparation used the vortex-sonication method which was made in five formulae with variations in the concentration ratio of phosphatidylcholine and tween-80 (95:05, 90:10, 85:15, 80:20, and 75:25). The results show that all five formulae have different morphological forms. The results of statistical tests using One-Way ANOVA finds a significant effect (p-value) of the edge activator concentration on the diffusion rate of diclofenac sodium transfersom.
Keywords
Full Text:
PDFReferences
Multazar, A., Nursiah, S., Rambe, A., dan Harahap, Ida S., 2012. Ekspresi cyclooxygenase-2 (COX-2). ORLI
Tan Hoan, Tjay, dan Kirana Rahardja. 2007. Obat-Obat Penting Khasiat, Penggunaan dan Efek-Efek Sampingnya. Edisi Keenam. Jakarta: PT. Elex Media Komputindo
Amit K N, B Mohanty, and Kalyan K S. 2010. Comparative Evaluation Of in Vitro Diclofenac Sodium Permeability Across Excised Mouse Skin From Different Common Pharmaceutical Vehicles. International Journal of PharmTech Research
J. V. Willis, M. J. Kendall, R. M. Flinn, D. P. Thornhill, P. G. Welling. 1979. The Pharmacokinetics of Diclofenac Sodium Following Intravenous and Oral Administration. Eur J Clin Pharmacol
Merin P. Eldhose, Flowerlet Mathew, Neethusha J. Mathew. 2016. Transfersomes: A Review. International Journal Of Pharmacy And Pharmaceutical Research.
Jacob L, Anoop KR. 2013. A Review On Surfactants As Edge Activator In Ultradeformable Vesicles For Enhanced Skin Delivery. Int J Pharm Bio Sci.
Wiranti Anggraini, Erny Sagita, Iskandarsyah Iskandarsyah. 2017. Effect Of Hydrophilicity Surfactants Toward Characterization And In Vitro Transfersomes Penetration In Gels Using Franz Diffusion Test. International Journal of Applied Pharmaceutics.
Wu, Pey-Shiuan & Li, Yu-Syuan & Kuo, Yi-Ching & Tsai, Suh-Jen & Lin, Chih-Chien. 2019. Preparation and Evaluation of Novel Transfersomes Combined with the Natural Antioxidant Resveratrol. Molecules.
Akib, Halimahtussaddiyah dan Prawesti. 2014. Preparasi Fenilbutazon dalam Pembawa Vesikular Etosom dengan Berbagai Variasi Konsentrasi Fosfatidilkolin dan Etanol. Medula.
Mohanraj, V.J., and Chen, Y. 2006. Nanoparticles – A Review. Tropical Journal of Pharmaceutical Research.
Dali, S.M. 2015. Pengaruh Dimetil Sulfoksida (DMSO) terhadap Penetrasi Krim Asam Kojat secara In Vitro. Skripsi. Universitas Negeri Gorontalo. Gorontalo.
Abolfazl Akbarzadeh, Rogaie Rezaei-Sadabady, Soodabeh Davaran, Sang Woo Joo, Nosratollah Zarghami, Younes Hanifehpour, Mohammad Samiei, Mohammad Kouhi and Kazem Nejati-Koshki. 2013. Liposome: Classification, Preparation, and Applications. Nanoscale Research Letters.
Sari, R. Permata. 2018. Formulasi dan Karakterisasi Fisetin Transfersom dengan Metode Hidrasi Lapis Tipis. Surakarta: Universitas Setia Budi
Go´mez-Hens A, Manuel Ferna´ndez-Romero J. 2005. The Role of Liposomes in Analytical Processes. Trends Anal. Chem.
Ghada M. El Zaafarany, Gehanne A.S. Awad, Samar M. Holayel, Nahed D. Mortada. 2010. Role of Edge Activators and Surface Charge in Developing Ultradeformable Vesicles with Enhanced Skin Delivery. International Journal of Pharmaceutics
DOI: https://doi.org/10.37311/jsscr.v3i2.11914
Refbacks
- There are currently no refbacks.
Copyright (c) 2021 Journal Syifa Sciences and Clinical Research
| EDITORIAL OFFICE OF JOURNAL SYIFA SCIENCES AND CLINICAL RESEARCH |
| Department of Pharmacy, Gorontalo State University Jl. Jenderal Sudirman No.6, Kota Gorontalo, Provinsi Gorontalo 96128, Indonesia |
| Email: info.jsscr@ung.ac.id Google Scholar : JOURNAL SYIFA SCIENCES AND CLINICAL RESEARCH |
