Formulasi Sediaan Salep Bisul dari Ekstrak Daun Bungur (Lagerstroemia speciosa L. Pers)

Abstract

Staphylococcus aureus is a normal flora of the skin and mucous membranes in humans, it can cause human infection in the form of boils. One example of antimicrobials that can be obtained from nature is the flower plant because it contains active substances, namely saponins, flavonoids, and tannins. To increase the effectiveness and convenience of using bungur leaves, it is necessary to formulate it in a more practical form such as a preparation. This study aims to identify the active fraction of the leaf extract of bungur (Lagerstroemia speciosa L. Pers) in boils ointment against Staphylococcus aureus bacteria. The extraction method was used  the maceration method, which was followed by the preparation of a boil ointment formulation, then tested against the Staphylococcus aureus bacteria. The diameter of the resistance formed was measured and statistically analyzed using the Completely Randomized Design (CRD) method. The results showed that the average resistance diameter of 1% bungur leaf ointment was 11.5 mm, 5% was 12.7 mm, 10% was 15.8 mm, and positive control was 16.5 mm. It was concluded that the effective concentration of bungur leaf extract in the ointment preparation in inhibiting the growth of Staphylococcus aureus was 1%.