Gambaran Penggunaan Obat Antipsikotik pada Pasien Skizofrenia di Puskesmas Kota Gorontalo

Herlina Jusuf, Madania Madania, Fika Nuzul Ramadhani, Dizky Ramadani Putri Papeo, Maryam Kalasi

Abstract


Schizophrenia is one of the most common forms of psychotic mental disorder, with the main symptoms being the absence of self-understanding (insight) and the inability to assess reality (reality testing ability is disturbed). This study aimed to determine the description of the antipsychotic drug's usage, including the drug classes, types, doses, and medication rules in schizophrenia patients at the Kota Selatan Public Health Center, Gorontalo City. This observational study used secondary data and was conducted retrospectively. Further, data obtained from the medical records of 25 schizophrenia patients were analyzed univariately. The results disclosed that schizophrenia was more experienced by men (60%), more prevalent in the age range of 36-45 years (52%), and unmarried (48%)The most widely used antipsychotic drugs were atypical groups (72%). The most widely used type of drug was Risperidone 2 mg with a rule of use of 2 x 1 (39%) and 1 x 1 (9%). Clozapine, 25 mg. with a rule of 2 x 1 was 14%, and 1 x 1 was 9%. Meanwhile, the had 28% consisting typical group only of chlorpromazine 25 mg with tule of use of 1x 1 (12%), haloperidol with a dose of 1.5 mg with a rule of use of 2 sikzonoate 25 mg/ml with 1 x 1 was 5%.


Keywords


Schizophrenia; Medication; Antipsychotics

Full Text:

PDF

References


Sovitriana, R. 2019. Dinamika Psikologi kasus Penderita Skizofrenia. Sidoarjo: Uwais Inspirasi Indonesia.

WHO. Schizophrenia. 2019. Available from: https://www.who.int/news-room/fact-sheets/detail/schizophrenia.

Kemenkes Kesehatan RI, 2019, Profil Kesehatan Indonesia Tahun 2018. Jakarta: Kemenkes.

Perhimpunan Dokter Spesialis Kedokteran jiwa Indonesia (PDSKJI) 2011, Konsensus Penatalaksanaan Gangguan Skizofrenia, Jakarta.

WHO. Schizophrenia. 2018. Available from: https://www.who.int/news-room/fact-sheets/detail/schizophrenia

Yulianty, MD, Cahaya, N & Srikartika, VM 2017, ‘Studi penggunaan antipsikotik dan efek samping pada pasien skizofrenia di rumah sakit jiwa Sambang Lihum Kalimantan Selatan, Jurnal Sains Farmasi & Klinis, vol. 3 , no. 2.

NHS, Diakses pada 2023. Schizophrenia

Yanti dan Dwi Andayani, 2020. Evaluasi Tepat Pasien, Tepat Obat, Dan Tepat Dosis Penggunaan Antipsikotik Pasien Skizofrenia Di Rumah Sakit Jiwa Provinsi NTB, Jurnal Insan Farmasi Indonesia. Hal 111-120

Hanif dan Noor, 2021. Gambaran penggunaan obat antipsikotik pada pasien skizorenia di rumah sakit jiwa Dr. Soeharto Heerdjen Periode januari-Juni, Jurnal Farmakologi, Vol 2. No 1.

Girsang. P, G., Tarigan. G, M., Pakpahan., E, A, 2020. Karateristik Pasien Skizofrenia. Jurnal Kedokteran Methodist, Vol. 13 No. 1.

Farizah. N, A., Fitriany. E, Yuni. E, 2020. Hubungan Fungsi Sosial Dengan Kualitas Hidup Pasien Skizofrenia Rawat Jalan Di RSJD Atma Husada Mahakam Samarinda. Jurnal Psikologi, 2 (2), 43-50.

Wahyudi. A, & Fibriana. I, A. 2016. Faktor Resiko Terjadinya Skizofrenia (Studi Kasus di Wilayah Kerja Puskesmas Pati II), Public Health Perspective Journal 1 (1) .

DiPiro, C. G, Yee L, Posey M. 2020. 11th Edition Pharmacotherapy : A Pathophysiologic Approach.

Roh, D., J. Chang., S. Yoon dan C. Kim. 2015. Antipsychotic prescribing patterns in first- episode schizophrenia: A Five- year Comparison. Clinical Psichopharmacology and Neurosciences. 13 (1): 275-282

Yulianty, MD, Cahaya, N & Srikartika, VM 2017, ‘Studi penggunaan antipsikotik dan efek samping pada pasien skizofrenia di rumah sakit jiwa Sambang Lihum Kalimantan Selatan, Jurnal Sains Farmasi & Klinis, vol. 3 , no. 2.

Roberts, R., A. Naesham., C. Lambrinudi dan A. Khan. 2018. A Quantitative Analysis of Antipsychotic Prescribing Trends for the Treatment of schizophrenia in England and Wales. Journal of the Royal Society of Medicine. 9 (4): 1-7.

Hanif dan Noor, 2021. Gambaran penggunaan obat antipsikotik pada pasien skizorenia di rumah sakit jiwa Dr. Soeharto Heerdjen Periode januari-Juni, Jurnal Farmakologi, Vol 2. No 1.

Julaeha, Ananda, V. D., Pradana, D. A. 2016. Gambaran Efek Amping Antipsikotik Pada Pasien Skizofrenia Pada Bangsal Rawat Inap Di Rs Grhasia Yogyakarta, Jurnal Farmasains, 3 (1): 35-41

Handayani DS, Cahaya N, Srikartika VM. 2018. Pengaruh Pemberiann Kombinasi Antipsikotik Terhadap Efek Samping Sindrom Ekstrapiramidal Pada Pasien Skizofrenia Di Rumah Sakit Jiwa Sambang Lihum. Farmaka : 15 (3): 86-95.

Meilina A.N., Cahaya N. dan Putra P.M.A., 2022. Analisis Trend Peresepan Golongan Antipsikotik Tipikal Dan Atipikal Di Tiga Puskesmas Di Kota Banjarmasin Periode 2019-2020. Jurnal Sains Kesehatan, Vol 4. No 4. P ISSN:2303-0267, e-ISSN: 2407-6082

Surbakti, Tetty A. Sinaga dan Artha Y. Sianipar, 2022. Profil penggunaan obat antipsikotik pada pasien orang dengan gangguan jiwa (ODGJ) di UPT. Puskesmas Helvetia Kota Medan, Journal of pharmauceutical and science, Vol 5, No 2. Pp 187-192.

DiPiro, JT, Wells BG, Schwinghammer TL , Dipiro CV. 2015. Pharmacotherapy A Pathophysiologic Approach. Edisi ke 9. New York: McGraw-Hill.

Swayami, I. G. A. V. 2014. Aspek Biologi Triheksilfenidil di Bidang Psikiatri. Jurnal Ilmiah Kedokteran, 89-93.

Rahaya, Anggie & Noor Cahaya, 2016. Studi Retrospektif Penggunaan Triheksilfenidil Pada Pasien Skizofrenia Rawat Inap Yang Mendapat Terapi Antipsikotik Di Rumah Sakit Jiwa Sambang Lihum. Jurnal Farmasi Galenika, Vol. 2 (2): 124-131

Motika, P., Smith, M. C., 2010. Carbamazepine, in: Panayiotopoulus, C. P (Ed), Atlas of Epilepsies, springer London, London, pp, 1713-1718.

Ranti, I, Octaviany, A. F dan Kinanti, S., 2015. Analisis Efekivitas Terapi Dan Biaya Antara Haloperidol Kombinasi Dan Risperidon Kombinasi Pada Terapi Skizofrenia Fase Akut Analisis Terapeutic And Coat Efectivenes Of Combination Therapy Between Risperidon And Haloperidol On Acute Phase Of Sch, 15 (1), Pp57-64.

Mawar D.Y., Norr. C & Valentina. M.S, 2017, Studi Penggunaan Antipsikotik Dan Efek Samping Pada Pasien Skizofrenia Di Rumah Sakit Jiwa Sambang Lihun Kalimantan Selatan, Jurnal Sain Farmasi Dan Klinis, 3 (2), 153-164.

Indriani A., Ardiningrum W, dan Febrianti Y., 2019. Studi Penggunaan Kombinasi Antipsikotik Pada Pasien Skizofrenia Di Rumah Sakit Yogyakarta. Majalah Farmasetika,4 (Suppl 1), 201-211.

MIMS. 2020. Risperidone: Indication, Dosage, Side Effect, Precaution.

Lacy, C. F., Armstrong, L., Golgman, M. P., Lance, L. L., 2008, Drug Information Handbook, 17th ed., Lexi-Copm Inc., New York.

Telles-Correia D, Barbosa A, Cortez-Pinto H, Campos C, Rocha NBF, Machado S. 2017, Psychotropic drugs and liver disease : A critical review pharmacokineticks and liver toxicity. World J Gastrointest Pharmacol Ther.6 (1): 128-33.

Jesić MP, Jesić A, Filipović JB, Zivanović O. Extrapyramidal syndromes caused by antipsychotics. Med Pregl. 2012;65(11–12):521–6

Hariyani, Yuliastuti F, Kusuma T.M. 2016. Pharmaciana. Pola Pengobatan Pasien Schizophrenia Program Rujuk Balik di Puskesmas Mungkid Periode Januari-Juni 2014., Vol. 6 No.1, 2016: 63-70. Universitas Muhammadiyah Magelang.

Ren YH, Wang, Xiao L. 2013. Improving Myelin Oligodendrocyte Related Dysfunction: A New Mechanism of Antipsychotics in The Treatment of Schizophrenia. International Journal of Neuropsychopharmacology. 16:691–700.

Fujimaki, K., T. Takahashi., S. Morinobu., 2012. Association of Typical versus Atypical Antipsychotics with Symptoms and Quality of Life in Schizophrenia. Influence of Antipsychotics in Schizophrenia. 7:1-10.

Hendra G.A., Aditya M., & Hastati I.W., 2020, Analisis Hubungan Kualitas Hidup Terhadap Penggunaan Kombinasi Obat Antipsikotik Pada Pasien Skizofrenia, Jurnal Kesehatan Dr. Soebandi, Vol 8, No. 2, 128-134.

Maramis. 2009. Catatan Ilmu Kedokteran Edisi 2. Surabaya: Airlangga




DOI: https://doi.org/10.37311/jsscr.v6i1.23849

Refbacks

  • There are currently no refbacks.


Copyright (c) 2024 Journal Syifa Sciences and Clinical Research

EDITORIAL OFFICE OF JOURNAL SYIFA SCIENCES AND CLINICAL RESEARCH
  Department of Pharmacy, Gorontalo State University
Jl. Jenderal Sudirman No.6, Kota Gorontalo, Provinsi Gorontalo 96128, Indonesia
 Email: info.jsscr@ung.ac.id
Google Scholar : JOURNAL SYIFA SCIENCES AND CLINICAL RESEARCH

Creative Commons License

Journal Syifa Sciences and Clinical Research (JSSCR) is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.