Formulasi Self-Nanoemulsifiying Drug Delivery System (SNEDDS) Asam Mefenamat menggunakan VCO dengan Kombinasi Surfaktan Tween dan Span

Muhamad Handoyo Sahumena, Suryani Suryani, Neni Rahmadani


Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) which has analgesic, anti-inflammatory and antipyretic effects. Mefenamic acid works by inhibiting prostaglandin synthesis as an inflammatory mediator. Mefenamic acid has low drug solubility and a long process of dissolution in the body which greatly affects the speed of absorption and bioavailability of the drug. In this study, mefenamic acid nanoemulsion formulation was carried out through a Self-Nanoemulsifying Drug Delivery System (SNEDDS) delivery system. SNEDDS is a drug delivery method through isotropic oil extraction, surfactants, cosurfactans and drug that form oil in water (m/a) emulsions which when in contact with the water phase in the digestive tract wiil from a nanoemulsion that occurs spontaneously so that the drug dissolves with a particle size small so as to increase the effective surface area for absorption. The purpose of the study was to determine the ratio of surfactant and cosurfactant composition to the optimum formula of SNEDDS of mefenamic acid with VCO as an oil phase. The SNEDDS formula was obtained by mixing the surfactants tween 80 and span 80, cosurfactant PEG 400 and VCO as the oil phase using the characterization of determining the optimum formula, namely emulsion formation, transmittance and emulsification time. The composition of the optimum formula of SNEDDS of mefenamic acid is 1 mL VCO; 1 mL PEG 400; 6 mL tween 80; 1 mL span 80. Optimum formula showed clear emulsion results, with transmittance values of 89,04% and emulsification time under 1 minute. In this study produced the optimum formula SNEDDS the met the criteria based on droplet size parameters of 153,5 nm, potential zeta value of 8,2 mV and showed good stability.


Mefenamic acid, Nanoemulsion, SNEDDS, VCO

Full Text:



Reynold, J.E.F., 1982, Martindale The Extra Pharmacopeia, 28 th ed, London : The Pharmaceutical Press

Wilmana, P.F., 1995, Farmakologi dan Terapi Edisi V, Jakarta: Bagian Farmakologi, Fakultas Kedokteran Universitas Indonesia.

Sriamornsak, P., Sontaya, L., Suchada, P., Punyanutch, M., Zongkang, H., 2015, A New Self-Emulsifying Formulation Of Mefenamic Acid With Enhanced Drug Dissolution, Asian Journal Of Pharmaceutical Sciences, 10(2) : 121-127

Rao, P. V., and Nagabhushanam, V. M., 2011, Enhancement of Dissolution Profile of Mefenamic Acid by Solid Dispersion Technique, International Journal of Research In Pharmacy And Chemistry, 1 (4) : 1127-1134.

Ghosh P.K., Majithiya, R.J., Umrethia, M. L. dan Murthy, R. S. R. 2006, Design and development of microemulsion drug delivery system of acyclovir for improvement of oral bioavailability, AAPS Pharm Sci Tech, 7(3):172–177.

Porras, M., Soran, C., Gonzales, C., Martinez, A., Guinart, A., Gutierrez, J.M., 2004, Studies Of Formation of W/O Nano Emulsions, Colloid Surf A, 2(49) : 115-118

Patel, J., Kevin, G., Patel, A., Raval, M., & Sheth, N., 2011, Design and Development of a Self-Nanoemulsifying Drug Delivery System for Telmisartan for Oral Drug Delivery, Int. J. Pharm. Investig., 1 (2) : 112-118

Rane, S. S. and Anderson, B. D., 2008, What Determines Drug Solubility in Lipid Vehicles: Is it Predictable, Advanced Drug Delivery Reviews, 60 : 638

Wasan, E. K., Bartlett, K., Gershkovich, P., Sivak, O., Banno, B., Wong, Z., Gagnon, J., Gates, B., Leon, C. G. and Wasan, K. M., 2009, Development and Characterization of Oral Lipid-based Amphotericin B Formulations with Enhanced Drug Solubility, International Journal of Pharmaceutics, 37(2): 76-84.

Gupta, P.K., Pandit, J.K., Kumar, A., Swaroop, P., Gupta, S., 2010, Pharmaceutical Nanotechnology Novel Nanoemulsion High Energy Emulsification Preparation, Evaluation, and Application. The Pharma Research.

Yuliani, S.H., Medaliana, H., Stephanie, Bety, P., and Enade P.I., 2016, Perbandingan Stabilitas Fisis Sediaan Nanoemulsi Minyak Biji Delima Dengan Fase Minyak Long-Chain Triglyceride Dan Medium-Chain Triglyceride, Traditional Medicine Journal, 21(2) : 94

Date, A.A. dan Nagarsenker, M.S. 2007, Design and evaluation of selfnanoemulsifiying drug delivery system (SNEDDS) for cefpodoxime proxetil, Int. J. Pharm., 329(1-2):166-172.

Kim, Cheng-ju, 2005, Advanced Pharmaceutics : Physicochemical Principles, CRC Press LLC, Florida : 214-235.

Danov, K.D. 2001, On the Viscosity of Dilute Emulsions, J. Colloid Interface Sci., 235(1):144–149.

Chen, M.L. 2008, Lipid excipients and delivery systems for pharmaceutical development: a regulatory perspective, Adv. Drug Deliv. Rev., 60(6):768–777

Rowe, R.C., Sheskey, P.J., and Quinn, M.E., 2009, Handbook of Pharmaceutical Excipients, 6th edition, Pharmaceutical Press and American Pharmacists Association 2009, Washington D.C. : 580-584.

Wahyuningsih, I., Widyasari, P., 2015, Optimasi Perbandingan Tween 80 Dan Polietilenglikol 400 Pada Formula Self Nanoemulsifying Drug Delivery System (SNEDDS) Minyak Biji Jinten Hitam, PHARMACY, 12 (2) : 223-241

Makadia, Ms. Hiral A., Bhatt, Ms. Ami Y., Parmar, Mr. Ramesh B., Paun, Ms., 2013, Self-nano Emulsifying Drug Delivery System (SNEDDS): Future Aspect, Asian J. Pharm. Res., 3 (1) : 21-27.

Date, A.A., Desai, N., Dixit, R. dan Nagarsenker, M. 2010., Self nanoemulsifying drug delivery systems: Formulation insights, applications and advances, Nanomed., 5(10):1595–1616



  • There are currently no refbacks.

Copyright (c) 2019 Journal Syifa Sciences and Clinical Research

  Department of Pharmacy, Gorontalo State University
Jl. Jenderal Sudirman No.6, Kota Gorontalo, Provinsi Gorontalo 96128, Indonesia

Creative Commons License

Journal Syifa Sciences and Clinical Research (JSSCR) is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.