Uji Aktivitas Antihiperlipidemia Ekstrak Etanol Daun Notika (Arcboldiodendron calosericeum Kobuski) Terhadap Kadar Kolesterol Total Tikus (Rattus norvegicus) Jantan Galur Wistar

Nuralifah Nuralifah, Wahyuni Wahyuni, Parawansah Parawansah, Ulan Dwi Shintia

Abstract


Hyperlipidemia is an increase of lipid due to excessive fat consumption, that the intake and alteration of lipid is not balanced. Notika are plants that contain secondary metabolites in the form of flavonoids, tannins, saponins and triterpenoids which are antioxidant compounds that are thought to have the effect of reducing blood lipids. This study aims to determine the effect of ethanol extract of leaves of Notika on decreasing total cholesterol levels in rats induced by egg and propylthiouracil (PTU). This research was experimental in 6 groups, namely 4 groups given ethanol extract of leaves of Notika at a dose of 50 mg/kgBB, 100 mg/kgBB, 200 mg/kgBB, and 300 mg/kgBB, one group was given Na CMC 0.5% as a negative control, and one group was given simvastatin 10 mg as a positive control. The results showed that the ethanol extract of the leaves of Notika significantly reduced the total cholesterol level of rats with a significant value <0.05 and 300 mg/kgBB is an effective dose to reduce total cholesterol level.

Keywords


Notika, Archboldiodendron calosericeum Kobuski, total cholesterol

Full Text:

PDF

References


Underwood JCE. Aterosklerosis.Didalam: Sarjadi,editor. Patologi Umum dan Sistemik Edisi 2. Jakarta:EGC,1999:326-29.

Handoko T, Suyatna F.D. Hipolipidemik. Di dalam: Ganiswara S G, Setiabudy R, Suyatna F D, Purwantyastuti, Nafrialdi, editor. Farmakologi dan Terapi edisi 5. Jakarta. Bagian Farmakologi FKUI, 2007: 373-388.

Allo, I.G., Pemsi, M.W., dan Henoch, A., 2013, Uji Efek Ekstrak Etanol Daun Jambu Biji (Psidium guajava L) Terhadap Kadar Kolesterol Total Tikus Wistar (Rattus norvegicus), Jurnal e-Biomedik, 1(1)

Arief, M.I., Riky N., Indra T.B., Muhammad B.H., 2012, Potensi Bunga Karamunting (Melastoma malabathricum L.) Terhadap Kadar Kolesterol Total Dan Trigliserida Pada Tikus Putih Jantan Hiperlipidemia Yang Diinduksi Propiltiourasil, Prestasi,1 (2)

Azizah, B., dan Nina S., 2013. Standarisasi Parameter Non Spesifik dan Perbandingan Kadar Kurkumin Ekstrak Etanol dan Ekstrak Terpurifikasi Rimpang Kunyit Kunyit, Jurnal Ilmiah Kefarmasian, 3 (1)

Brass, L.J., 1933, British Papua New Guinea: Central Division, Mt. Tafa, landslip regrowths, 2400 m, Also in Herbarium, Journal Of The Arnold Arboretum 21(2) :143. 1940.

Chairunnisa, N.H., 2015, Efectivity of Roselle Extract (Hibiscus sabdariffa L.) as Treatment For Hyperlipidemia, Jurnal Majority, 4(4)

Departemen Kesehatan RI, 1985, Cara Pembuatan Simplisia, Direktorat Jendral PO, Jakarta.

Departemen Kesesehatan RI, 1995. Materia Medika, Jilid VI, Diktorat Jenderal POM, Jakarta.

Depertemen Kesehatan RI, 2000. Parameter Standar Umum Ekstrak Tumbuhan Obat, Diktorat Jendral POM, Jakarta.

Direktorat Jendral POM, 2008, Farmakope Herbal Indonesia Edisi 1, Dep Kesehat RI: Jakarta.

Dipiro, J.T., Barbara, G.W, Terry, L.S., dan Cecilly, V.D., 2012, Pharmacotherapy Handbook, The Mc Graw-Hill Companies, New York

Erwinanto, 2013, Pedoman Tatalaksana Dislipidemia, Edisi 1, PERKI

Global Biodiversity Information Facility, 2017, Arcboldiodendron calosericeum subsp. Merillianum (Kobuski) Barker http://www.tropicos.org/Name/50 233818. Published In: Journal of the Arnold Arboretum 21 (2) : 143.1940

Global Biodiversity Information Facility Backbone Taxonomy, 2005, Arcboldiodendron calosericeum subsp. Merillianum (Kobuski) Barker http://www.gbif.org/species/7313963. Published In: Journal of the Arnold Arboretum 21 (2) : 143.1940

Harborne, J.B., 2006, Metode Fitokimia: Penuntun Cara Modern Menganalisis Tumbuhan, ITB Press, Bandung

Harjana, T., 2011, Kajian Tentang Potensi Bahan-Bahan Alami Untuk Menurunkan Kadar Koleterol Darah, Prosiding Seminar Nasional Penelitian

Hayudanti, D., Inggita, K., dan Kanthi, P.T., 2016, Pengaruh Pemberian Jus Jambu Biji Merah (Psidium guajava) dan Jeruk Siam (Citrus nobilis) terhadap Kadar High Density Lipoprotein (HDL) pada Pasien Dislipidemia, Indonesian Journal of Human Nurition, 3(1)

Jones, W.P. dan Kinghorn, A.D., 2006, Extraction of plant secondary metabolites, In:L Sarker, S.D., Latif, Z. dan Gray, A.I,. Natural Products Isolation, 2nd Ed. New Jersey Humana Press.

Mukhriani, 2014, Ekstraksi, Pemisahan Senyawa, dan Identifikasi Senyawa Aktif, Jurnal Kesehatan, 7 (2)

Nuralifah Nuralifah, Asriullah Jabbar, Parawansah Parawansah, Ria Agus Iko., (2018). Uji Toksisitas Akut Ekstrak Etanol Daun Notika (Archboldiodendron calosercium (Kobuski)) Terhadap Larva Artemia salina Leach dengan Menggunakan Metode Brine Shrimp Lethality Test (BSLT), Jurnal Pharmauho Vol 4, No 1

Nofianti, T., Devi, W., dan Yulius, P., (2015), Uji Aktivitas Ekstrak Etanol Krop Kubis Putih (Brassica oleracea L.var. capitata) Terhadap Kadar Kolesterol Total Dan Trigliserida Serum Darah Tikus Putih Jantan Galur Wistar, Jurnal Kesehata Bakti Tunas Husada, 14(1)

Prashant, 2011, Phytochemical Screening and Extraction, Internationale Pharmaceutica Sciencia, 1(1):1-9.

Robinson, T., 1995, Kandungan Senyawa Oraganik Tumbuhan Tinggi., ITB. Bandung.

Sahidin, I., 2012, Mengenal Senyawa Alami, Unhalu Press, Kendari.

Umami, S.R., Sarifa, S.H., Rosita, F., dan Ahefman, H., 2016, Uji Penurunan Kolesterol Pada Mencit Putih (Mus Musculus) Secara In-Vivo Menggunakan Ekstrak Metanol Umbi Talas (Colocasia Esculenta L) Sebagai Upaya Pencegahan Cardiovascular Disease, J. Pijar MIPA, 11(2)

Wurdianing, I., SA Nugraheni, Zen, R., 2014, Efek Ekstrak Daun Sirsak (Annona muricata Linn) Terhadap Profil Lipid Tikus Putih Jantan (Rattus Norvegicus), Jurnal Gizi Indonesia, 3 (1)




DOI: https://doi.org/10.37311/jsscr.v2i1.2704

Refbacks

  • There are currently no refbacks.


Copyright (c) 2019 Journal Syifa Sciences and Clinical Research

EDITORIAL OFFICE OF JOURNAL SYIFA SCIENCES AND CLINICAL RESEARCH
  Department of Pharmacy, Gorontalo State University
Jl. Jenderal Sudirman No.6, Kota Gorontalo, Provinsi Gorontalo 96128, Indonesia
 Email: info.jsscr@ung.ac.id
Google Scholar : JOURNAL SYIFA SCIENCES AND CLINICAL RESEARCH

Creative Commons License

Journal Syifa Sciences and Clinical Research (JSSCR) is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.