Artikel Review: Peran Antioksidan Flavonoid dalam Menghambat Radikal Bebas
Abstract
Degenerative diseases are now one of the diseases with the highest prevalence in the world of health. One of the causes of various degenerative diseases is free radicals. In order to prevent the increasing growth of free radicals, a compound called an antioxidant is needed. Antioxidant compounds can be obtained naturally, one of which is from plants. Plants have various secondary metabolite compounds, one of which has the potential as an antioxidant is flavonoids. Flavonoids have three working mechanisms to prevent free radicals, including inhibiting the formation of ROS (Reactive Oxygen Species), destroying (Reactive Oxygen Species), and regulating and protecting with antioxidants. The purpose of compiling this article review is to provide information and knowledge about the role of flavonoids as antioxidants in plants. This review article is compiled using a comparative method and searches from various sources such as (Google, Google Scholar, NCBI, PubMed). Based on the results of the research that has been carried out, it is known that flavonoid compounds have the potential as antioxidants that have been tested in vitro and in vivo. This shows that flavonoid compounds are able to act as antioxidants to prevent the growth of free radicals.
Keywords
Full Text:
PDFReferences
I. F. Kurniawati and S. Sutoyo, “Review Artikel: Potensi Bunga Tanaman Sukun (Artocarpus Altilis [Park. I] Fosberg) Sebagai Bahan Antioksidan Alami,” Unesa J. Chem., vol. 10, no. 1, pp. 1–11, 2021, doi: 10.26740/ujc.v10n1.p1-11.
F. A. Sinaga, “Stress Oksidatif Dan Status Antioksidan Pada Aktivitas Fisik Maksimal,” J. Gener. Kampus, vol. 9, no. 2, pp. 176–189, 2016.
P. I. Sayakti, N. Anisa, and H. Ramadhan, “Antioxidant activity of methanol extract of cassava leaves (Manihot esculenta Crantz) using CUPRAC method,” J. Ilm. Farm., pp. 97–106, 2022, doi: 10.20885/jif.specialissue2022.art12.
M. D. Hidayati, T. Ersam, K. Shimizu, and S. Fatmawati, “Antioxidant activity of Syzygium polynthum extracts,” Indones. J. Chem., vol. 17, no. 1, pp. 49–53, 2017, doi: 10.22146/ijc.23545.
H. Ramadhan, S. Purnama, and P. I. Sayakti, “Uji Aktivitas Antioksidan Fraksi N-Heksan dari Ekstrak Metanol Daun Binjai Mangifera caesia Jack. Ex. Wall Menggunakan Metode DPPH,” J. Ilmu Kefarmasian Indones., vol. 20, no. 1, p. 55, 2022, doi: 10.35814/jifi.v20i1.1133.
O. Malinda and A. Syakdani, “Review Artikel POTENSI ANTIOKSIDAN DALAM KELOPAK BUNGA ROSELLA (Hibiscus sabdariffa L.) SEBAGAI ANTI-AGING POTENTIAL OF ANTIOXIDANT IN FLOWER CLASSROOM ROSELLA (Hibiscus sabdariffa L.) AS ANTI-AGING,” J. Kinet., vol. 11, no. 03, pp. 60–65, 2020, [Online]. Available: https://jurnal.polsri.ac.id/index.php/kimia/index60
R. Riskianto, M. Windi, K. Karnelasatri, and M. Aruan, “Antioxidant Activity of 96% Ethanol Extract of Pepaya Jepang Leaves (Cnidoscolus aconitifolius (Mill.) I. M. Johnst) Using DPPH Method (1,1-diphenyl-2-picrylhydrazyl),” Borneo J. Pharm., vol. 5, no. 4, pp. 315–324, 2022, doi: 10.33084/bjop.v5i4.3511.
N. N. W. Udayani, P. D. S. Wiguna, E. Cahyaningsih, and I. G. A. A. K. Wardani, “Skrining Fitokimia dan Aktivitas Antioksidan Ekstrak Daun Benalu Jeruk (Dendrophthoe glabrescens (Blakely) Barlow) dengan Pelarut n-Heksan dan Etanol,” J. Ilm. Medicam., vol. 9, no. 2, pp. 150–157, 2023, doi: 10.36733/medicamento.v9i2.7136.
J. Sukweenadhi et al., “Antioxidant activity screening of seven Indonesian herbal extract,” Biodiversitas, vol. 21, no. 5, pp. 2062–2067, 2020, doi: 10.13057/biodiv/d210532.
A. Ullah et al., “Important flavonoids and their role as a therapeutic agent,” Molecules, vol. 25, no. 22, pp. 1–39, 2020, doi: 10.3390/molecules25225243.
M. C. Dias, D. C. G. A. Pinto, and A. M. S. Silva, “Plant flavonoids: Chemical characteristics and biological activity,” Molecules, vol. 26, no. 17, pp. 1–16, 2021, doi: 10.3390/molecules26175377.
S. Noer, R. D. Pratiwi, and E. Gresinta, “Penetapan Kadar Senyawa Fitokimia (Tanin, Saponin dan Flavonoid) sebagai Kuersetin Pada Ekstrak Daun Inggu (Ruta angustifolia L.),” J. Eksakta, vol. 18, no. 1, pp. 19–29, 2018, doi: 10.20885/eksakta.vol18.iss1.art3.
M. M. Vuolo, V. S. Lima, and M. R. Maróstica, “Chapter 2 Phenolic Compounds Structure, Classification, and Antioxidant Power,” in Bioactive Compounds, 2019, pp. 33–50. doi: 10.1016/b978-0-12-814774-0.00002-5.
I. Susila Ningsih, M. Chatri, and L. Advinda, “Flavonoid Active Compounds Found In Plants Senyawa Aktif Flavonoid yang Terdapat Pada Tumbuhan,” Serambi Biol., vol. 8, no. 2, p. 2023, 2023.
F. Alfaridz and R. Amalia, “Review Jurnal : Klasifikasi Dan Aktivitas Farmakologi Dari Senyawa Aktif Flavonoid,” Farmaka, vol. 3, pp. 1–9, 2019, doi: https://doi.org/10.24198/jf.v16i3.17283.g8932.
T. yang Wang, Q. Li, and K. shun Bi, “Bioactive flavonoids in medicinal plants: Structure, activity and biological fate,” Asian J. Pharm. Sci., vol. 13, no. 1, pp. 12–23, 2018, doi: 10.1016/j.ajps.2017.08.004.
W. N. Munthe, R. Riskianto, D. Juvi, and J. Novia, “Antioxidant, Total Phenolic, and Total Flavonoid of 70% Ethanol Extract of Avocado Seeds (Persea americana Mill.),” Pharmacogn. J., vol. 15, no. 4, pp. 599–605, 2023, doi: 10.5530/pj.2023.15.126.
P. S. Widyawati, T. D. W. Budianta, Y. D. W. Werdani, and M. O. Halim, “Aktivitas Antioksidan Minuman Daun Beluntas Teh Hitam (Pluchea indica Less-Camelia sinensis),” Agritech, vol. 38, no. 2, p. 200, 2018, doi: 10.22146/agritech.25699.
A. A. Bhutto, Ş. Kalay, S. T. H. Sherazi, and M. Culha, “Quantitative structure-activity relationship between antioxidant capacity of phenolic compounds and the plasmonic properties of silver nanoparticles.,” Talanta, vol. 189, pp. 174–181, Nov. 2018, doi: 10.1016/j.talanta.2018.06.080.
H. Musdja MY, Rahman HA, “Antioxidant Activity of Catechins Isolate of Uncaria Gambier Roxb in Male Rats,” LIFE Int. J. Heal. Life-Sciences, vol. 4, no. 2, pp. 34–46, 2018, doi: 10.20319/lijhls.2018.42.3446.
J. Treml and K. Šmejkal, “Flavonoids as Potent Scavengers of Hydroxyl Radicals.,” Compr. Rev. food Sci. food Saf., vol. 15, no. 4, pp. 720–738, Jul. 2016, doi: 10.1111/1541-4337.12204.
B. Arifin and S. Ibrahim, “Struktur, Bioaktivitas Dan Antioksidan Flavonoid,” J. Zarah, vol. 6, no. 1, pp. 21–29, 2018, doi: 10.31629/zarah.v6i1.313.
Indah Cikita, Ika Herawati Hasibuan, and Rosdanelli Hasibuan, “PEMANFAATAN FLAVONOID EKSTRAK DAUN KATUK (Sauropus androgynus (L) Merr) SEBAGAI ANTIOKSIDAN PADA MINYAK KELAPA,” J. Tek. Kim. USU, vol. 5, no. 1, pp. 45–51, 2016, doi: 10.32734/jtk.v5i1.1524.
K. Zouari Bouassida, S. Makni, A. Tounsi, L. Jlaiel, M. Trigui, and S. Tounsi, “Effects of Juniperus phoenicea Hydroalcoholic Extract on Inflammatory Mediators and Oxidative Stress Markers in Carrageenan-Induced Paw Oedema in Mice,” Biomed Res. Int., vol. 2018, 2018, doi: 10.1155/2018/3785487.
S. R. Dewi, B. D. Argo, and N. Ulya, “Kandungan Flavonoid dan Aktivitas Antioksidan Ekstrak Pleurotus ostreatus,” Rona Tek. Pertan., vol. 11, no. 1, pp. 1–10, 2018, doi: 10.17969/rtp.v11i1.9571.
D. K. Norhabibah, Ali Rakhman Hakim, “Uji Kuantitatif Flavonoid Total dan Aktivitas Antioksidan Ekstrak Daun Kacapiring (Gardenia jasminoides Ellis),” Indones. J. Pharm. Nat. Prod., vol. 02, pp. 4–7, 2019, doi: https://doi.org/10.35473/ijpnp.v5i2.1799.
E. F. Yanti and N. Purwanti, “Penetapan Kadar Falvonoid Total Dan Uji Aktivitas Ekstrak Etanol Daun Makadamia (Macadamia integrifolia) Dengan Metode DPPH,” J. Islam. Pharm., vol. 7, no. 2, pp. 100–103, 2023, doi: 10.18860/jip.v7i2.17522.
M. Sari, R. N. Ulfa, M. P. Marpaung, and Purnama, “Penentuan Aktivitas Antioksidan dan Kandungan Flavonoid Total Ekstrak Daun Papasan (Coccinia grandis L.) Berdasarkan Perbedaan Pelarut Polar,” KOVALEN J. Ris. Kim., vol. 7, no. 1, pp. 30–41, 2021, doi: 10.22487/kovalen.2021.v7.i1.15437.
J. Wang, Y. Bian, Y. Cheng, R. Sun, and G. Li, “Effect of lemon peel flavonoids on UVB-induced skin damage in mice,” RSC Adv., vol. 10, no. 52, pp. 31470–31478, 2020, doi: 10.1039/d0ra05518b.
P. A. Haeria, Hermawati, “Penentuan kadar flavonoid total dan aktivitas antioksidan ekstrak etanol daun bidara,” J. Pharm. Med. Sci., vol. 1, no. 2, pp. 57–61, 2016.
P. Riwanti, F. Izazih, and A. Amaliyah, “Pengaruh Perbedaan Konsentrasi Etanol pada Kadar Flavonoid Total Ekstrak Etanol 50,70 dan 96% Sargassum polycystum dari Madura,” J. Pharm. Anwar Med., vol. 2, no. 2, pp. 35–48, 2020, doi: 10.36932/jpcam.v2i2.1.
E. J. Simanjuntak and Z. Zulham, “Superoksida Dismutase (Sod) Dan Radikal Bebas,” J. Keperawatan Dan Fisioter., vol. 2, no. 2, pp. 124–129, 2020, doi: 10.35451/jkf.v2i2.342.
S. F. . Paat, Fatimawali, and I. Antasionasti, “Antioxidant Activity Test of Ethanol of Lemon Peel (Citrus lemon L.) by DPPH Method (1.1-Diphenil-2-Picrylhdarzyl),” PHARMACON J. Ilm. Farm. – UNSRAT, vol. 11, no. 1, pp. 1315–1320, 2022.
DOI: https://doi.org/10.37311/jsscr.v6i2.27055
Refbacks
- There are currently no refbacks.
Copyright (c) 2024 Journal Syifa Sciences and Clinical Research (JSSCR)
EDITORIAL OFFICE OF JOURNAL SYIFA SCIENCES AND CLINICAL RESEARCH |
Department of Pharmacy, Gorontalo State University Jl. Jenderal Sudirman No.6, Kota Gorontalo, Provinsi Gorontalo 96128, Indonesia |
Email: info.jsscr@ung.ac.id Google Scholar : JOURNAL SYIFA SCIENCES AND CLINICAL RESEARCH |