Activity Tests Of Sunscreen Emulgel Preparation of Tamanu Oil (Calophyllum inophyllum L.) Combined With Titanium Dioxide (TiO2)

Ni Wayan Devy Indah Lestari, Reslely Harjanti, Dewi Ekowati

Abstract


Sunlight is the main source of UV rays, exposure to UV rays can have a negative impact on human skin. These negative impacts can be prevented by using sunscreen. The effectiveness of sunscreen can be increased by combining UV filters and natural ingredients. This study aims to determine variations in the concentration of tamanu oil (Calophyllum inophyllum L.) in an emulgel preparation of a combination of tamanu oil and TiO2 which can provide protection as a Sun Protection Factor (SPF) with good physical quality and stability.Tamanu oil is made in 3 concentration variations of 10%; 15%; and 20% and combined with 7% titanium dioxide. Emulgel preparations as a whole were tested for physical quality and stability tests were carried out using the cycling test method. Testing of sunscreen activity in preparations was carried out in vitro using a UV-Vis spectrophotometer at a wavelength of 290-320 nm. The research results were processed statistically.The results of the sunscreen activity test for the emulgel preparation, a combination of tamanu oil and TiO2, showed that all formulas had activity as a sunscreen. The highest SPF value of the emulgel combination of tamanu oil and TiO2 was in formula 6 (20% oil and TiO2) of 9.6 and after the stability test the SPF formula 6 (20% oil and TiO2) was 9.0.


Keywords


Tamanu oil; Ttitanium dioxide (TiO2); Sunscreen; SPF

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References


Latha MS, Martis J, Shobha V, Shinde RS, Bangera S, Krishnankutty B, et al. Sunscreening agents: A review. Journal of Clinical and Aesthetic Dermatology 2013;6:16–26.

Trivedi M, Murase J. Titanium Dioxide in Sunscreen. Application Titanium Dioxide. Intechopen 2017. https://doi.org/10.5772/intechopen.68886.

Shi L, Shan J, Ju Y, Aikens P, Prud’homme RK. Nanoparticles as delivery vehicles for sunscreen agents. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2012;396:122–9. https://doi.org/10.1016/j.colsurfa.2011.12.053.

Ebrahimzadeh MA, Enayatifard R, Khalili M, Ghaffarloo M, Saeedi M, Charati JY. Correlation between sun protection factor and antioxidant activity, phenol and flavonoid contents of some medicinal plants. Iranian Journal of Pharmaceutical Research 2014;13:1041–8.

Rosado C, Tokunaga VK, Sauce R, De Oliveira CA, Sarruf FD, Parise-Filho R, et al. Another reason for using caffeine in dermocosmetics: Sunscreen adjuvant. Frontiers in Physiology 2019;10:1–8. https://doi.org/10.3389/fphys.2019.00519.

Gunawan Y, Pangkahila A, Darwinata AE. Topical administration of Tamanu Oil (Calophyllum inophyllum) inhibited the increase of matrix metalloproteinase-1 (MMP-1) expressions and decrease of collagen dermis amount in male wistar rats exposed to ultraviolet B. Neurologico Spinale Medico Chirurgico 2021;4:114–8. https://doi.org/10.36444/nsmc.v4i3.186.

Ácsová A, Hojerová J, Janotková L, Bendová H, Jedličková L, Hamranová V, et al. The real UVB photoprotective efficacy of vegetable oils: in vitro and in vivo studies. Photochemical and Photobiological Sciences 2021;20:139–51. https://doi.org/10.1007/s43630-020-00009-3.

Rejeki S, Wahyuningsih SS, Farmasi P, Mulia PB, Farmasi P, Mulia PB. Formulasi Gel Tabir Surya Minyak Nyamplung ( Tamanu Oil ). Univ Res Colloq 2015:97–103.

Handayani IA, Purba AV, Rahmat D. Nilai Antioksidan dan SPF dari Kombinasi Minyak Biji Nyamplung (Calophyllum inophyllum L) dan Minyak Kelapa Sawit (Elaeis guineensis). Majalah Farmaseutik 2020;16:176. https://doi.org/10.22146/farmaseutik.v16i2.52244.

Yadav SK, Mishra MK, Tiwari A, Shukla A. Emulgel: a New Approach for Enhanced Topical Drug Delivery. International Journal of Current Pharmaceutical Research 2016;9:15. https://doi.org/10.22159/ijcpr.2017v9i1.16628.

Kementerian Kesehatan Republik Indonesia. Farmakope Indonesia edisi VI. 2020.

M. Heinrich, J. Barnes, S. Gibbons and EMW. Farmakognosi dan Fisioterapi (terj.). Jakarta: EGC,pp; 2010.

Hurria. Formulasi, Uji Stabilitas Fisik, Dan Uji Aktivitas Sediaan Gel Hand sanitizer Dari Air Perasan Jeruk Nipis (Citrus Aurantifolia SWINGLE) Berbasis Karbomer. Jurnal Farmasi FIK UINAM 2014;2(1):52–9.

Wiyono AS, Lestari TP, Wardani VS. Pengaruh HPMC Sebagai Gelling Agent pada Optimasi Formula Gel Ekstrak Kasar Bromelin Kulit Nanas (Ananas comossus L . Merr). Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya 2020;1:52–9.

Safitri EG, Parfati N. Stabilitas Fisika-Kimia Sediaan Krim Dan Gel Esktrak Kental Daun Kelor (Moringa Oleifera). Calyptra 2020;9:1–21.

Usman Y, Muin R. Formulasi dan Uji In Vitro Nilai Sun Protecting Factor (SPF) Krim dari Cangkang Telur Ayam Ras. Jurnal MIPA 2020;10:25. https://doi.org/10.35799/jmuo.10.1.2021.31188.

Mirawati. Formulasi Shampo Krim Cair Dari Kombinasi Ekstrak Daun Waru (Hibiscus tiliaceus L.) Dan Sari Buah Jeruk Nipis (Citrus aurantifolia Swingle.). As-Syifaa 2012;04(01).

Aisyah A.N., Arfiyanti Yusuf N, Nur Aisyah Akademi Farmasi Kebangsaan Makassar A. Formulation of Emulgel Ethanol Extract of Mullberry (Morus alba L.) with Various Concentration of Span 80 ® and Tween 80 ®. Journal of Pharmaceutical and Medicinal Sciences 2017;2:77–80.

Sinata N dan Mistawati A. Formulasi Dan Uji Aktivitas Emulgel Minyak Ikan Gabus (Channa striata) Sebagai Penyembuh Luka Bakar. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) 2020;6:253–68. https://doi.org/10.22487/j24428744.2020.v6.i2.15013.

Mishra A, Mishra A, Chattopadhyay P. Assessment of in vitro sun protection factor of Calendula officinalis L. (asteraceae) essential oil formulation. Journal of Young Pharmacists 2012;4:17–21. https://doi.org/10.4103/0975-1483.93575.

Raharivelomanana P, Ansel JL, Lupo E, Mijouin L, Guillot S, Butaud JF, et al. Tamanu oil and skin active properties: From traditional to modern cosmetic uses. OCL - Oilseeds and fats, Crops and Lipids 2018;25. https://doi.org/10.1051/ocl/2018048.

Cahya ERP, Ekowati D, Ningsih D. Formulating Oil Emulgel of Nyamplung (Calophyllum inophyllum L) with Variations of HPMC and Activity Testing for Incision in Rabbit New Zealand. Indonesian Journal of Pharmaceutical Education 2022;2:161–75. https://doi.org/10.37311/ijpe.v2i3.15455.

Hutajulu EC, Nurjazuli N, Wahyuningsih NE. Hubungan Jenis Minyak Goreng, Suhu, dan PH terhadap Kadar Asam Lemak Bebas pada Minyak Goreng Pedagang Penyetan. Media Kesehatan Masyarakat Indonesia 2020;19:375–8. https://doi.org/10.14710/mkmi.19.5.375-378.

Ketaren S. Pengantar Teknologi Minyak dan Lemak Pangan. Jakarta: UI Press; 2012.

Garg, A., D. Aggarwal, S. Garg dan AKS. Spreading of Semisolid Formulation. USA: Pharmaceutical Technology; 2002.

Dewi R, Anwar E, S YK. Uji Stabilitas Fisik Formula Krim yang Mengandung Ekstrak Kacang Kedelai (Glycine max). Pharmaceutical Sciences and Research 2014;1:194–208. https://doi.org/10.7454/psr.v1i3.3484.

Pertiwi D, Desnita R, Luliana S. Pengaruh pH Terhadap Stabilitas Alpha Arbutin dalam Gel Niosom. Majalah Farmaseutik 2020;16:91. https://doi.org/10.22146/farmaseutik.v16i1.49446.

Anief M. Ilmu Meracik Obat. Yogyakarta: Gadjah Mada University Press; 2007.

Shovyana HH, Zulkarnain AK. Stabilitas Fisik dan Aktivitas Krim W/O Ekstrak Etanolik Buah Mahkota Dewa (Phaleria macrocarph(scheff.) Boerl,) Sebagai Tabir Surya. Traditional Medicine Journal 2013;18:2013.

Samudra AG, Ramadhani N, Sani K F, Febriyani U. Pembuatan Virgin Coconut Oil (Vco) Dengan Metode Pengasaman Sebagai Krim Tabir Surya Berbahan Aktif Tio2. Jurnal Ilmiah Manuntung 2020;6:11–6.

Yuliantari NWA, Widarta IWR, Permana IDGM. Pengaruh Suhu dan Waktu Ekstraksi Terhadap Kandungan Flavonoid dan Aktivitas Antioksidan Daun Sirsak (Annona muricata L.) Menggunakan Ultrasonik The Influence of Time and Temperature on Flavonoid Content and Antioxidant Activity of Sirsak Leaf (Annona mur. Media Ilmiah Teknologi Pangan 2017;4:35–42.




DOI: https://doi.org/10.37311/ijpe.v3i2.21225

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