Application of Fourier Transform Infrared Spectroscopy (FTIR) for Quantitative Analysis of Pharmaceutical Compounds

Gavriel Fauzan Faturachman, Ajeng Ayu Ramanda, Sinta Maharani, Larasati Ainun Latif, George Arthurito Goncalves Belo, Seno Grafi Al Ayubi

Abstract


Fourier Transform Infrared Spectroscopy (FTIR) is an infrared spectroscopy equipped with a Fourier transform for detection and analysis of spectral results. This method is used to qualitatively and quantitatively analyze organic and inorganic molecules with a wavenumber range of 14000 cm-1–10 cm-1. Based on these wavenumbers, the infrared region is divided into three regions, namely near infrared, mid infrared, and far infrared. The tool used in this method is an FTIR spectrophotometer whose working principle based on the interaction between the energy and the material. This method are fast, non-destructive, simple sample preparation, ease of use, using little solvent so it is environmentally friendly when compared to other HPLC and spectroscopic methods. But the sampling space in this method is relatively small so that it can block infrared rays. The research method that used is systematic literature review (SLR) from 20 research articles in national and international journals with publication years between 2005-2023. Based on the results of quantitative analysis of amoxicillin, pentoxyphylline, ciprofloxacin, diclofenac sodium, sodium ceftriaxone, ibuprofen, valsartan, and cefadroxil compounds in drugs can be analyzed using this method because they include organic compounds and are analyzed in the mid infrared. All concentrations of compounds analyzed meet the content requirements according to the Indonesian Pharmacopoeia IV Edition, which is not less than 90% and not more than 110%.

Keywords


Spectroscopy; FTIR; Quantitative Analysis; Drugs; Compounds in Drugs

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DOI: https://doi.org/10.37311/ijpe.v5i1.23309

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