Efektivitas Pemberian Gel Supernatan Bakteri Asam Laktat Terhadap Luas Luka Insisi pada Tikus Wistar

Olvaria Misfa, Atifa Aliyah Nur Rahmah, Eliya Mursyida, Nursal Hasbi

Abstract


Wounds are a disruption of tissue continuity due to physical, thermal, chemical, medical treatments, and physiological conditions.In 2014, in the United States there were 17,200,000 hospital visits by outpatients (57.8%) and inpatients (42.2%) resulting from acute wounds with scar tissue formation and post-operative wound infections. Infection by normal flora is one of the factors inhibiting wound healing. Lactic acid bacteria are known to have the ability to heal wounds so its can be used as another alternative in wound treatment. This research was to analyze the effectiveness of lactic acid bacteria supernatant gel on the area of incision wounds in Wistar rats. This study used a randomized posttest only with control group. The samples used were 21 Wistar rats which were divided into 3 groups randomly (randomization), namely the positive control group (C1) given 10% povidone iodine, the negative control group (C2) given gel base, and the treatment group (P) given bacterial supernatant gel. lactic acid. The mean wound area (mm2) in groups C1, C2, and P on day 3 was 23.79; 24.85; 29.69, on the 7th day it was 8.58; 27.88; 20.01, and the 14th day is 0.15; 5.64; 0.16. The One Way ANOVA and Kruskal Wallis tests did not show significant differences between groups with a p value > 0.05. Lactic acid bacteria supernatant gel was able to minimize the incision wound area of Wistar rats.

 


Keywords


Wound healing; Lactid acid bacteria; Supernatant gel

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References


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DOI: https://doi.org/10.37311/ijpe.v4i2.26011

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