Interaksi Obat Pada Pasien Diabetes Melitus Tipe 2 Dengan Penyakit Penyerta Di Rumah Sakit Otanaha Kota Gorontalo

Nur Rasdianah, Faramita Hiola, A. Mu’thi Andy Suryadi, Athira Sri Wahyuni Gani


As the numbers of cases continue to soar, diabetes mellitus or DM is one the most common disease in Indonesia. The WHO predicts that in 2030, numbers of diabetics in Indonesia will rise up to 21.3 million people, compared to 8.4 million people in 2000. Regarding the treatment, most of diabetes cases are commonly treated with pharmacological therapy. In this regard, polypharmacy and medications-related problems might occur during the treatment to control blood glucose level that is concurrent with the treatment of other diseases. Drug Interaction is a common medication-related problem. The present study is aimed to investigate the cases of drug interaction in patients with type-2 DM with comorbid diseases during the period of January-December 2019 in Otanaha Hospital, Gorontalo. As based on the inclusion criteria, the study involved 92 patients with type-2 DM and comorbid disease involved combination of metformin-glimepiride (47%), insulin (19%), metformin (14%), and glimepiride (9%). Moreover, based on the observation, minor interaction occurred the most (47%), followed by moderat interaction (31%) and major interaction. To sum up, the cases of drug interaction in patients with type-2 DM and comorbid disease in Otanaha Hospital, Gorontalo are relatively high. It is further concluded that the pharmacist’s role is influential to supervise and monitor the patients medication intake.


Diabetes Melitus, Interaction, Medicaton

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WHO (Word Health Organization). 2011. Diabetes Melitus. Hipokrates : Jakarta

ADA (American Diabetes Association). 2016. Standards of Medical Care in Diabetes 2016. Diabetes Care

Ganiswara, S G. 2000. Farmakologi dan Terapi, Edisi IV. Bagian Farmakologi Fakultas Kedokteran Universitas Indonesia : Jakarta.

Kementrian Kesehatan RI. Riset Kesehatan Dasar (RISKESDAS). Jakarta : Balitbang RI

Alonso-Magdalena P, Ropero AB, Carrera MP, Cederroth CR, Baquie´ Met all, 2008. Pancreatic Insulin Content Regulation by the Estrogen Receptor ERα, PLoS ONE, (3):4

Letchuman GR, Wan Nazaimoon WM, Wan Mohamad WB, Chandran LR, Tee GH, Jamaiyah H, 2013 . Prevalence of diabetes in the Malaysian National Health Morbidity Survey III 2006. Med J Malay ;65(3):180–6.

Maryam, S. 2013. Pedoman Pencegahan Jatuh Bagi Lansia Di Rumah. Jakarta: Poltekkes Kemenkes Jakarta lll.

Carlisle BA, Kroon LA, Koda-Kimble MA. 2005. Diabetes Melitus. In: Young LY, Koda-Kimble MA, Eds. Applied Therapeutics: The Clinical Use of Drugs. 8th ed. Vancouver, WA: Applied Therapeutics, Inc.

Ferina D M, Jhons F S, Aila K, 2016. Tatalaksana Farmakologi Diabetes Meitus Tipe 2 pada Wanita Lansia dengan Kadar Glukosa Tidak Terkontrol. Lampung : Fakultas Kedokteran Universitas Lampung

Tatro, D S. 2009. Drug Interaction Facts. San Carlos California: A Wolters Kluwer Health Inc.

Baxter, K. 2010. Stockley’s Drug Interactions 9th Edition. Chicago : Pharmaceutical Press

Pande Made D R S, 2014. Studi Literatur Interaksi Obat Pada Peresepan Pasien Diabetes Melitus Tipe 2 Di Instalasi Rawat Jalan RSUD Panembahan Senopati Bantul Yogyakarta Periode Desember 2013. Yogyakarta : Fakultas Farmasi Universitas Sanata Dharma

Drug Interaction Checker, 2015. Medscape Refenrence Drug, Disease and Procedures. diakses pada 16 juli 2020

Stockley, I H. 2008. Stockley’s Drug Interaction Eight Edition. Great Britain: Pharmaceutical Press

Stockley, I H. 2008. Stockley’s Drug Interaction Eight Edition. Great Britain: Pharmaceutical Press



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