Activity Of A Gel Combination Of Pandan Wangi (Pandanus amaryllifolius Roxb) and Snail Mucus (Achatina Fulica) On Burn Wounds In Male White Rats (Rattus Norvegicus) Wistar Strains

Andre Prayoga, Modesta Harmoni Tarigan, Ferdinand Paulus Ginting, Rialita Lifiani, Zumaira Zumaira

Abstract


Burns are damage to skin tissue due to thermal trauma. This research aimed to determine the combination of Pandan Wangi and snail mucus used to treat burns and determine the optimal formula. The research was pure with only a randomized control design, including F1 being given placebo gel, F1 (10%:10%), F2 (10%:15%), F3 (10%:20%), and F4 being given bioplacenton. The gel evaluation and tested for the ability to treat burns on rats for about 21 days. The combination gel made a homogenous formulation with a pH 6 based on pH paper while pH meter results were around 6,27- 6,35 cm, a spread of 5,70-6,60 cm, and a viscosity value of 5.600-7.600 cps that was stable for 3 weeks of storage. This evaluation’s findings are consistent with the provisions of National Standard Indonesia (SNI). The activity optimal combination gel obtained by examining the average diameter and discoloration were 10%:20% (0,5560 cm), 10%:15% (0,8120 cm), 10%:10% (0,9860 cm), bioplacenton (0,4780 cm), and placebo gel (1,5340 cm). On the 21st day, the skin condition of K1, K2, K3, and K4 was normal, however, K0 was not normal. The statistical analysis data is normally distributed (p≥0,05), homogeneous (p≥0,05), and a significant difference in all groups (p<0,05). According to the experiment, three gel combination of Pandan Wangi and snail mucus have an effect on healing burns but 10%:20% (F3) could accelerate the optimal healing process.

Keywords


Pandan Wangi; Snail Mucus; Burn Wound

Full Text:

PDF

References


P. A. Z. Hasibuan et al., “Antimicrobial and antihemolytic properties of a CNF/AgNP-chitosan film: A potential wound dressing material,” Heliyon, vol. 7, no. 10, p. e08197, 2021.

A. Prayoga, “Aktivitas Antioksidan Ekstrak N-Heksan, Etilasetat, dan Etanol Daun Pirdot (Saurauia vulcani, Korth) dengan Metode Pemerangkapan DPPH,” 2018.

P. RSP and S. AISIYAH, “Formulasi Gel Kombinasi Lendir Bekicot (Achatina fulica Ferr) dan Lidah Buaya (Aloe vera) sebagai Bahan Aktif untuk Terapi Luka Bakar Gel Formulation Combination Snail Slime (Achatina fulica Ferr) and Aloe vera as Active Material for Treatment of Burn.”

A. Prayoga, Pengujian Patch Nanopartikel Perak Kitosan Dengan Pembawa Nanoserat Selulosa Terhadap Penyembuhan Luka Eksisi Pada Tikus Hiperglikemia, vol. 3, no. 2. Universitas Sumatera Utara, 2021.

A. Prayoga, “Comparison Study of Caffeine Levels of Coffee Bean ( Coffea Sp .) and Brands of Coffee Powder Circulate in Banda Aceh City,” vol. 3, no. 1, pp. 96–102, 2023, doi: 10.37311/ijpe.v3i1.18913.

V. K. Sugiaman, “Peningkatan penyembuhan luka di mukosa oral melalui pemberian Aloe vera (Linn.) secara topical,” Maranatha J. Med. Heal., vol. 11, no. 1, p. 151777, 2011.

A. Prayoga and P. A. Z. Hasibuan, “Synthesis of Silver Nanoparticles for Antibacterial Activity against Staphylococcus Aureus and Escherichia Coli,” Asian J. Pharm. Res. Dev., vol. 9, no. 5, pp. 67–73, 2021.

S. Maimunah and A. Prayoga, “Formulation of Red Beet (Beta vulgaris. L) and Aloe Vera (Aloe vera) Gel Extracts as Anti-Aging,” J. Pembelajaran Dan Biol. Nukl., vol. 9, no. 2, pp. 449–461, 2023, doi: 10.36987/jpbn.v9i2.4478.

F. Shoviantari, S. Fajriyah, E. Agustin, and S. Khairani, “UJI AKTIVITAS GEL LENDIR BEKICOT (Achatina fulica) SEBAGAI PENYEMBUHAN LUKA SAYAT,” As-Syifaa J. Farm., vol. 13, no. 1, pp. 12–19, 2021.

A. Prayoga, R. Fitri, G. Anastasia, and H. D. Syahputra, “Evaluasi Perencanaan Obat Di Puskesmas Tanah Tinggi , Kecamatan Binjai Timur , Kota Binjai Tahun,” vol. 01, no. 01, pp. 69–75, 2023.

P. A. Z. Hasibuan et al., “Antimicrobial And Antihemolytic Properties Of A Cnf/Agnp-Chitosan Film: A Potential Wound Dressing Material,” Heliyon, vol. 7, no. 10, p. e08197, 2021, doi: 10.1016/j.heliyon.2021.e08197.

S. Tambunan and T. N. S. Sulaiman, “Formulasi gel minyak atsiri sereh dengan basis HPMC dan Karbopol,” Maj. Farm., vol. 14, no. 2, pp. 87–95, 2018.

E. D. Marbun, A. Prayoga, and A. Y. Sianipar, “Edukasi Pemanfaatan Suplemen Kesehatan Di lingkungan SD Negeri 053975 Stabat Lama Kabupaten langkat,” vol. 3, pp. 331–337, 2022.

A. Y. Sianipar et al., “Activity of a Gel Combination of Aloe Vera ( Aloe Vera ( L ) Burm . F .) and Snail Mucus ( Achatina fulica ( Ferussac , 1821 )) on Burn Wounds in Male White Rats ( Rattus norvegicus ) Wistar Strains,” vol. 3, no. 2, pp. 186–194, 2023, doi: 10.37311/ijpe.v3i2.19343.

S. Ahn et al., “Soy Protein/Cellulose Nanofiber Scaffolds Mimicking Skin Extracellular Matrix for Enhanced Wound Healing,” Adv. Healthc. Mater., vol. 7, no. 9, 2018, doi: 10.1002/adhm.201701175.

A. Prayoga, “Forte jurnal,” Forte J., vol. 02, no. 01, pp. 67–73, 2022.

E. D. Marbun, A. Prayoga, and A. Y. Sianipar, “Edukasi Pemanfaatan Suplemen Kesehatan Di Lingkungan SD Negeri 053975 Stabat Lama Kabupaten Langkat,” J. Abdimas Mutiara, vol. 3, no. 2, pp. 331–337, 2022.




DOI: https://doi.org/10.37311/ijpe.v3i3.24234

Refbacks

  • There are currently no refbacks.


Copyright (c) Andre Prayoga

Creative Commons License
Indonesian Journal of Pharmaceutical Education is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.